CD44 SPLICE VARIANTS - METASTASES MEET LYMPHOCYTES

被引：279

作者：

HERRLICH, P

ZOLLER, M

PALS, ST

PONTA, H

机构：

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 08期

关键词：

D O I：

10.1016/0167-5699(93)90141-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent discoveries of surface proteins involved in tumor metastasis formation have revived an old hypothesis that tumor cells may acquire, and use for their metastatic spreading, properties which lymphoid cells had developed to defend the organism against foreign antigens. Splice variants of CD44 and integrins are expressed on metastasizing tumor cells and also on leukocytes at defined stages of their differentiation. Expression and function appear to be essential not only for the generation of an immune response but also for the establishment of metastatic tumor colonies.

引用

收藏

页码：395 / 399

页数：5

相关论文

共 50 条

[1]

ANDERSON DC, 1987, ANNU REV MED, V38, P175, DOI 10.1146/annurev.med.38.1.175

[2] PARTICIPATION IN NORMAL IMMUNE-RESPONSES OF A METASTASIS-INDUCING SPLICE VARIANT OF CD44 [J].

ARCH, R ;

WIRTH, K ;

HOFMANN, M ;

PONTA, H ;

MATZKU, S ;

HERRLICH, P ;

ZOLLER, M .

SCIENCE, 1992, 257 (5070) :682-685

[3] CD44 IS THE PRINCIPAL CELL-SURFACE RECEPTOR FOR HYALURONATE [J].

ARUFFO, A ;

STAMENKOVIC, I ;

MELNICK, M ;

UNDERHILL, CB ;

SEED, B .

CELL, 1990, 61 (07) :1303-1313

[4] INVITRO AND INVIVO CONSEQUENCES OF VLA-2 EXPRESSION ON RHABDOMYOSARCOMA CELLS [J].

CHAN, BMC ;

MATSUURA, N ;

TAKADA, Y ;

ZETTER, BR ;

HEMLER, ME .

SCIENCE, 1991, 251 (5001) :1600-1602

[5] PRODUCTION OF SELF-DIRECTED ANTIBODY BY TUMOUR CELLS [J].

CHARNEY, J .

NATURE, 1968, 220 (5166) :504-&

[6] THE HYALURONATE RECEPTOR IS A MEMBER OF THE CD44 (H-CAM) FAMILY OF CELL-SURFACE GLYCOPROTEINS [J].

CULTY, M ;

MIYAKE, K ;

KINCADE, PW ;

SILORSKI, E ;

BUTCHER, EC ;

UNDERHILL, C .

JOURNAL OF CELL BIOLOGY, 1990, 111 (06) :2765-2774

[7] MONOCLONAL-ANTIBODY TO A HUMAN BRAIN-GRANULOCYTE-T LYMPHOCYTE ANTIGEN PROBABLY HOMOLOGOUS TO THE W 3-13 ANTIGEN OF THE RAT [J].

DALCHAU, R ;

KIRKLEY, J ;

FABRE, JW .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1980, 10 (10) :745-749

[8] ALTERATIONS IN INTEGRIN RECEPTOR EXPRESSION ON CHEMICALLY TRANSFORMED HUMAN-CELLS - SPECIFIC ENHANCEMENT OF LAMININ AND COLLAGEN RECEPTOR COMPLEXES [J].

DEDHAR, S ;

SAULNIER, R .

JOURNAL OF CELL BIOLOGY, 1990, 110 (02) :481-489

[9]

DENNING S M, 1989, FASEB Journal, V3, pA785

[10] MOLECULAR-CLONING OF CD44R1 AND CD44R2, 2 NOVEL ISOFORMS OF THE HUMAN CD44 LYMPHOCYTE HOMING RECEPTOR EXPRESSED BY HEMATOPOIETIC-CELLS [J].

DOUGHERTY, GJ ;

LANSDORP, PM ;

COOPER, DL ;

HUMPHRIES, RK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (01) :1-5

← 1 2 3 4 5 →