A MUTATION IN THE INSULIN-RECEPTOR GENE THAT IMPAIRS TRANSPORT OF THE RECEPTOR TO THE PLASMA-MEMBRANE AND CAUSES INSULIN-RESISTANT DIABETES

被引：147

作者：

ACCILI, D

FRAPIER, C

MOSTHAF, L

MCKEON, C

ELBEIN, SC

PERMUTT, MA

RAMOS, E

LANDER, E

ULLRICH, A

TAYLOR, SI

机构：

[1] GENENTECH INC,S SAN FRANCISCO,CA 94080

[2] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,ST LOUIS,MO 63110

[3] UNIV MARYLAND,DEPT INTERNAL MED,BALTIMORE,MD 21201

[4] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

[5] HARVARD UNIV,CAMBRIDGE,MA 02138

来源：

EMBO JOURNAL | 1989年 / 8卷 / 09期

关键词：

D O I：

10.1002/j.1460-2075.1989.tb08388.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：2509 / 2517

页数：9

共 53 条

[31] AN HSP70-LIKE PROTEIN IN THE ER - IDENTITY WITH THE 78 KD GLUCOSE-REGULATED PROTEIN AND IMMUNOGLOBULIN HEAVY-CHAIN BINDING-PROTEIN [J].

MUNRO, S ;

PELHAM, HRB .

CELL, 1986, 46 (02) :291-300

[32] DETECTION OF SINGLE BASE SUBSTITUTIONS BY RIBONUCLEASE CLEAVAGE AT MISMATCHES IN RNA-DNA DUPLEXES [J].

MYERS, RM ;

LARIN, Z ;

MANIATIS, T .

SCIENCE, 1985, 230 (4731) :1242-1246

[33]

ODAWARA M, 1989, IN PRESS SCIENCE

[34] DEFECTS IN HUMAN INSULIN-RECEPTOR GENE-EXPRESSION [J].

OJAMAA, K ;

HEDO, JA ;

ROBERTS, CT ;

MONCADA, VY ;

GORDEN, P ;

ULLRICH, A ;

TAYLOR, SI .

MOLECULAR ENDOCRINOLOGY, 1988, 2 (03) :242-247

[35] INSULIN-RECEPTORS ON CHINESE-HAMSTER OVARY (CHO) CELLS - ALTERED INSULIN BINDING TO GLYCOSYLATION MUTANTS [J].

PODSKALNY, J ;

MCELDUFF, A ;

GORDEN, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (01) :70-75

[36] A CHIMERIC RECEPTOR ALLOWS INSULIN TO STIMULATE TYROSINE KINASE-ACTIVITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR [J].

RIEDEL, H ;

DULL, TJ ;

SCHLESSINGER, J ;

ULLRICH, A .

NATURE, 1986, 324 (6092) :68-70

[37]

RONNETT GV, 1984, J BIOL CHEM, V259, P4566

[38] TUNICAMYCIN-MEDIATED DEPLETION OF INSULIN RECEPTORS IN 3T3-L1 ADIPOCYTES [J].

ROSEN, OM ;

CHIA, GH ;

FUNG, C ;

RUBIN, CS .

JOURNAL OF CELLULAR PHYSIOLOGY, 1979, 99 (01) :37-42

[39] A POINT MUTATION IN THE EXTRACELLULAR DOMAIN OF THE HUMAN CSF-1 RECEPTOR (C-FMS PROTO-ONCOGENE PRODUCT) ACTIVATES ITS TRANSFORMING POTENTIAL [J].

ROUSSEL, MF ;

DOWNING, JR ;

RETTENMIER, CW ;

SHERR, CJ .

CELL, 1988, 55 (06) :979-988

[40] PRIMER-DIRECTED ENZYMATIC AMPLIFICATION OF DNA WITH A THERMOSTABLE DNA-POLYMERASE [J].

SAIKI, RK ;

GELFAND, DH ;

STOFFEL, S ;

SCHARF, SJ ;

HIGUCHI, R ;

HORN, GT ;

MULLIS, KB ;

ERLICH, HA .

SCIENCE, 1988, 239 (4839) :487-491

← 1 2 3 4 5 6 →