A MUTATION IN THE INSULIN-RECEPTOR GENE THAT IMPAIRS TRANSPORT OF THE RECEPTOR TO THE PLASMA-MEMBRANE AND CAUSES INSULIN-RESISTANT DIABETES

被引：147

作者：

ACCILI, D

FRAPIER, C

MOSTHAF, L

MCKEON, C

ELBEIN, SC

PERMUTT, MA

RAMOS, E

LANDER, E

ULLRICH, A

TAYLOR, SI

机构：

[1] GENENTECH INC,S SAN FRANCISCO,CA 94080

[2] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,ST LOUIS,MO 63110

[3] UNIV MARYLAND,DEPT INTERNAL MED,BALTIMORE,MD 21201

[4] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

[5] HARVARD UNIV,CAMBRIDGE,MA 02138

来源：

EMBO JOURNAL | 1989年 / 8卷 / 09期

关键词：

D O I：

10.1002/j.1460-2075.1989.tb08388.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：2509 / 2517

页数：9

共 53 条

[1] A NEW ECORI POLYMORPHISM FOR THE INSULIN-RECEPTOR GENE [J].

ACCILI, D ;

ELBEIN, S ;

MCKEON, C ;

TAYLOR, SI .

NUCLEIC ACIDS RESEARCH, 1989, 17 (02) :821-821

[2]

ARAKI E, 1987, J BIOL CHEM, V262, P16186

[3] MULTIPLE INDEPENDENT ACTIVATIONS OF THE NEU ONCOGENE BY A POINT MUTATION ALTERING THE TRANSMEMBRANE DOMAIN OF P185 [J].

BARGMANN, CI ;

HUNG, MC ;

WEINBERG, RA .

CELL, 1986, 45 (05) :649-657

[4]

BARNES ND, 1974, DIABETOLOGIA, V10, P285

[5]

BEVINS CL, 1988, DNA PROT ENG TECHN, V1, P12

[6] A RECEPTOR-MEDIATED PATHWAY FOR CHOLESTEROL HOMEOSTASIS [J].

BROWN, MS ;

GOLDSTEIN, JL .

SCIENCE, 1986, 232 (4746) :34-47

[7] IMMUNOLOGICAL ABNORMALITIES IN INSULIN-RECEPTORS ON CULTURED EBV-TRANSFORMED LYMPHOCYTES FROM INSULIN-RESISTANT PATIENT WITH LEPRECHAUNISM [J].

CAMA, A ;

MARCUSSAMUELS, B ;

TAYLOR, SI .

DIABETES, 1988, 37 (07) :982-988

[8] STRUCTURAL ALTERATION OF VIRAL HOMOLOG OF RECEPTOR PROTOONCOGENE FMS AT CARBOXYL TERMINUS [J].

COUSSENS, L ;

VANBEVEREN, C ;

SMITH, D ;

CHEN, E ;

MITCHELL, RL ;

ISACKE, CM ;

VERMA, IM ;

ULLRICH, A .

NATURE, 1986, 320 (6059) :277-280

[9] CLOSE SIMILARITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND V-ERB-B ONCOGENE PROTEIN SEQUENCES [J].

DOWNWARD, J ;

YARDEN, Y ;

MAYES, E ;

SCRACE, G ;

TOTTY, N ;

STOCKWELL, P ;

ULLRICH, A ;

SCHLESSINGER, J ;

WATERFIELD, MD .

NATURE, 1984, 307 (5951) :521-527

[10] THE HUMAN INSULIN-RECEPTOR CDNA - THE STRUCTURAL BASIS FOR HORMONE-ACTIVATED TRANSMEMBRANE SIGNALING [J].

EBINA, Y ;

ELLIS, L ;

JARNAGIN, K ;

EDERY, M ;

GRAF, L ;

CLAUSER, E ;

OU, JH ;

MASIARZ, F ;

KAN, YW ;

GOLDFINE, ID ;

ROTH, RA ;

RUTTER, WJ .

CELL, 1985, 40 (04) :747-758

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