MK801 INDUCES C-FOS PROTEIN IN THALAMIC AND NEOCORTICAL NEURONS OF RAT-BRAIN

被引：52

作者：

DRAGUNOW, M

FAULL, RLM

机构：

[1] Department of Pharmacology, School of Medicine, University of Auckland, Auckland

来源：

NEUROSCIENCE LETTERS | 1990年 / 113卷 / 02期

关键词：

c-fos; MK-801; Neocortex; Thalamus;

D O I：

10.1016/0304-3940(90)90294-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MK801, a non-competitive NMDA receptor antagonist, leads to a dramatic induction of c-fos-like protein in neurons in deep layers of the neocortex, in dorsal and ventral midline thalamic nuclei and in neurons in the central grey of rat brain. This induction of c-fos by MK801 is dose- and time-dependent occurring within 2 h and dissipating by 24 h after injection (0.5-8.0 mg/kg, i.p.). The mechanism of this paradoxical induction of c-fos by MK801 is unclear, however the pattern of induction appears to follow the distribution of the antagonist-preferring NMDA receptor site. © 1990.

引用

页码：144 / 150

页数：7

共 15 条

[11] MAPPING PATTERNS OF C-FOS EXPRESSION IN THE CENTRAL-NERVOUS-SYSTEM AFTER SEIZURE [J].