MK801 INDUCES C-FOS PROTEIN IN THALAMIC AND NEOCORTICAL NEURONS OF RAT-BRAIN

被引：52

作者：

DRAGUNOW, M

FAULL, RLM

机构：

[1] Department of Pharmacology, School of Medicine, University of Auckland, Auckland

来源：

NEUROSCIENCE LETTERS | 1990年 / 113卷 / 02期

关键词：

c-fos; MK-801; Neocortex; Thalamus;

D O I：

10.1016/0304-3940(90)90294-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MK801, a non-competitive NMDA receptor antagonist, leads to a dramatic induction of c-fos-like protein in neurons in deep layers of the neocortex, in dorsal and ventral midline thalamic nuclei and in neurons in the central grey of rat brain. This induction of c-fos by MK801 is dose- and time-dependent occurring within 2 h and dissipating by 24 h after injection (0.5-8.0 mg/kg, i.p.). The mechanism of this paradoxical induction of c-fos by MK801 is unclear, however the pattern of induction appears to follow the distribution of the antagonist-preferring NMDA receptor site. © 1990.

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页码：144 / 150

页数：7

相关论文

共 15 条

[1] VIRAL AND CELLULAR FOS PROTEINS ARE COMPLEXED WITH A 39,000-DALTON CELLULAR PROTEIN [J].

CURRAN, T ;

VANBEVEREN, C ;

LING, N ;

VERMA, IM .

MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (01) :167-172

[2] LONG-TERM POTENTIATION AND THE INDUCTION OF C-FOS MESSENGER-RNA AND PROTEINS IN THE DENTATE GYRUS OF UNANESTHETIZED RATS [J].

DRAGUNOW, M ;

ABRAHAM, WC ;

GOULDING, M ;

MASON, SE ;

ROBERTSON, HA ;

FAULL, RLM .

NEUROSCIENCE LETTERS, 1989, 101 (03) :274-280

[3] GENERALIZED SEIZURES INDUCE C-FOS PROTEIN(S) IN MAMMALIAN NEURONS [J].

DRAGUNOW, M ;

ROBERTSON, HA .

NEUROSCIENCE LETTERS, 1987, 82 (02) :157-161

[4] AMYGDALA KINDLING AND C-FOS PROTEIN(S) [J].

DRAGUNOW, M ;

ROBERTSON, HA ;

ROBERTSON, GS .

EXPERIMENTAL NEUROLOGY, 1988, 102 (02) :261-263

[5] BRAIN INJURY INDUCES C-FOS PROTEIN(S) IN NERVE AND GLIAL-LIKE CELLS IN ADULT MAMMALIAN BRAIN [J].

DRAGUNOW, M ;

ROBERTSON, HA .

BRAIN RESEARCH, 1988, 455 (02) :295-299

[6] LOCALIZATION AND INDUCTION OF C-FOS PROTEIN-LIKE IMMUNOREACTIVE MATERIAL IN THE NUCLEI OF ADULT MAMMALIAN NEURONS [J].

DRAGUNOW, M ;

ROBERTSON, HA .

BRAIN RESEARCH, 1988, 440 (02) :252-260

[7] KINDLING STIMULATION INDUCES C-FOS PROTEIN(S) IN GRANULE CELLS OF THE RAT DENTATE GYRUS [J].

DRAGUNOW, M ;

ROBERTSON, HA .

NATURE, 1987, 329 (6138) :441-442

[8]

DRAGUNOW M, IN PRESS NEUROSCI LE

[9]

FRANZA BR, 1987, ONCOGENE, V1, P213

[10] 2 CLASSES OF N-METHYL-D-ASPARTATE RECOGNITION SITES - DIFFERENTIAL DISTRIBUTION AND DIFFERENTIAL REGULATION BY GLYCINE [J].

MONAGHAN, DT ;

OLVERMAN, HJ ;

NGUYEN, L ;

WATKINS, JC ;

COTMAN, CW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) :9836-9840