STUDIES ON THE CYTOPHILIC PROPERTIES OF HUMAN BETA-2-MICROGLOBULIN .2. ROLE OF HISTOCOMPATIBILITY ANTIGENS

被引：30

作者：

HESTER, RB ^{[1
]}

KUBO, RT ^{[1
]}

GREY, HM ^{[1
]}

机构：

[1] NATL JEWISH HOSP & RES CTR,DEPT MED,DENVER,CO 80206

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 02期

关键词：

D O I：

10.1111/j.1365-3083.1979.tb02714.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanism by which exogenously added β2m binds to lymphoid cells has been explored. In the mouse it has been shown that β2m remains associated with plasma membrane macromolecules following solubilization with NP‐40 and that approximately 25–30% of the binding could be accounted for by binding to H‐2 antigens. No binding to mouse immunoglobulin or Ia antigens could be detected. The sites for binding of the remainder of the cell‐hound β2m were not determined. Whereas normal human lymphocytes showed little or no capacity to bind exogenously added β2m, it was found that phytohaemagglutinin (PHA)‐stimulated cells could bind β2m. This binding occurred optimally 2 days after PHA stimulation. Approximately half of the binding could be accounted for by binding to HLA antigens. The possible significance of these findings with respect to cellular interactions involving major histocompatibility complex gene products in the immune response is discussed. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：125 / 134

页数：10

共 38 条

[21]

NEUPORTSAUTES C, 1974, J EXP MED, V139, P957

[22]

OFARRELL PH, 1975, J BIOL CHEM, V250, P4007

[23] HIGHLY PURIFIED PAPAIN-SOLUBILIZED HL-A ANTIGENS CONTAIN BETA2 MICROGLOBULIN [J].