COSECRETION OF AMYLIN AND INSULIN FROM ISOLATED RAT PANCREAS

被引：97

作者：

FEHMANN, HC ^{[1
]}

WEBER, V ^{[1
]}

GOKE, R ^{[1
]}

GOKE, B ^{[1
]}

ARNOLD, R ^{[1
]}

机构：

[1] UNIV MARBURG,DEPT INTERNAL MED,W-3550 MARBURG,GERMANY

来源：

FEBS LETTERS | 1990年 / 262卷 / 02期

关键词：

Amylin; Cosecretion; Insulin; Rat pancreas;

D O I：

10.1016/0014-5793(90)80210-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amylin, a 37 amino acid C-terminal amidated peptide is an integral part of secretory granules of pancreatic β-cells. Utilizing a specific radioimmunoassay system we demonstrate in the present study a cosecretion of amylin and insulin from the isolated rat pancreas. The secretion pattern of both peptides during glucose or glucose plus arginine stimulation is identical. The molar ratio of amylin amounts to 10% of that of insulin. The biological significance of amylin is still unknown, but a paracrine/endocrine role in glucose homeostasis is speculated. © 1990.

引用

页码：279 / 281

页数：3

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