BRANCHING PATTERN IN THE EVOLUTIONARY TREE FOR HUMAN MITOCHONDRIAL-DNA

被引：349

作者：

DIRIENZO, A

WILSON, AC

机构：

[1] Department of Molecular, University of California, Berkeley

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 05期

关键词：

POLYMERASE CHAIN REACTION; DIRECT SEQUENCING; CONTROL REGION; DISTRIBUTION OF PAIRWISE DIFFERENCES; POPULATION GROWTH;

D O I：

10.1073/pnas.88.5.1597

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Eighty-eight types of mitochondrial (mt) DNA were found by sequencing the most variable part of the control region from 117 Caucasians. In the tree relating those types, most of the branching events occur about two-thirds of the way from the root of the tree to the tips of the branches. Moreover, the distribution of sequence differences between all possible pairs of individuals is approximately Poisson. Other non-African populations show a similar pattern. Assuming a neutral model, these findings imply that the probability of survival of new lineages has undergone dramatic changes, probably due to population expansion. Conversely, African populations show multimodal distributions fitting with a model of constant population size.

引用

页码：1597 / 1601

页数：5

共 30 条

[11] GENERATION OF SINGLE-STRANDED-DNA BY THE POLYMERASE CHAIN-REACTION AND ITS APPLICATION TO DIRECT SEQUENCING OF THE HLA-DQA LOCUS [J].