A NOVEL METALLOPROTEINASE GENE SPECIFICALLY EXPRESSED IN STROMAL CELLS OF BREAST CARCINOMAS

被引：1097

作者：

BASSET, P

BELLOCQ, JP

WOLF, C

STOLL, I

HUTIN, P

LIMACHER, JM

PODHAJCER, OL

CHENARD, MP

RIO, MC

CHAMBON, P

机构：

[1] FAC MED STRASBOURG, INST CHIM BIOL,INSERM, UNITE BIOL MOLEC & GEN GENET 184,CNRS, F-67085 STRASBOURG, FRANCE

[2] CHU STRASBOURG, SERV ANAT PATHOL GEN, F-67098 STRASBOURG, FRANCE

来源：

NATURE | 1990年 / 348卷 / 6303期

关键词：

D O I：

10.1038/348699a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies. © 1990 Nature Publishing Group.

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页码：699 / 704

页数：6

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