A NOVEL METALLOPROTEINASE GENE SPECIFICALLY EXPRESSED IN STROMAL CELLS OF BREAST CARCINOMAS

被引：1097

作者：

BASSET, P

BELLOCQ, JP

WOLF, C

STOLL, I

HUTIN, P

LIMACHER, JM

PODHAJCER, OL

CHENARD, MP

RIO, MC

CHAMBON, P

机构：

[1] FAC MED STRASBOURG, INST CHIM BIOL,INSERM, UNITE BIOL MOLEC & GEN GENET 184,CNRS, F-67085 STRASBOURG, FRANCE

[2] CHU STRASBOURG, SERV ANAT PATHOL GEN, F-67098 STRASBOURG, FRANCE

来源：

NATURE | 1990年 / 348卷 / 6303期

关键词：

D O I：

10.1038/348699a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies. © 1990 Nature Publishing Group.

引用

页码：699 / 704

页数：6

共 50 条

[1]

Ahmed A, 1990, PATHOL ANNU 2, V25, P237

[2] TUMOR INTERACTIONS WITH THE VASCULATURE - ANGIOGENESIS AND TUMOR-METASTASIS [J].

BLOOD, CH ;

ZETTER, BR .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1032 (01) :89-118

[3]

COLLIER IE, 1988, J BIOL CHEM, V263, P6579

[4] DETECTION OF MESSENGER-RNAS IN SEA-URCHIN EMBRYOS BY INSITU HYBRIDIZATION USING ASYMMETRIC RNA PROBES [J].

COX, KH ;

DELEON, DV ;

ANGERER, LM ;

ANGERER, RC .

DEVELOPMENTAL BIOLOGY, 1984, 101 (02) :485-502

[5] CELL-TYPE-SPECIFIC CDNA PROBES AND THE MURINE-I REGION - THE LOCALIZATION AND ORIENTATION OF A-ALPHA-D [J].

DAVIS, MM ;

COHEN, DI ;

NIELSEN, EA ;

STEINMETZ, M ;

PAUL, WE ;

HOOD, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (07) :2194-2198

[6]

DECLERCK YA, 1989, J BIOL CHEM, V264, P17445

[7]

DEOME KB, 1978, CANCER RES, V38, P2103

[8]

ERICKSON HP, 1989, REV CELL BIOL, V5, P71

[9]

FERGUSON JE, 1990, J DIFFERENTIATION, V42, P199

[10] ORIGIN AND BIOLOGY OF CANCER METASTASIS [J].

FIDLER, IJ .

CYTOMETRY, 1989, 10 (06) :673-680

← 1 2 3 4 5 →