FIBROBLAST GROWTH FACTOR-I INDUCES PHOSPHOFRUCTOKINASE, FATTY-ACID SYNTHASE AND CA2+-ATPASE MESSENGER-RNA EXPRESSION IN NIH 3T3 CELLS

被引：42

作者：

HSU, DKW ^{[1
]}

DONOHUE, PJ ^{[1
]}

ALBERTS, GF ^{[1
]}

WINKLES, JA ^{[1
]}

机构：

[1] AMER RED CROSS,HOLLAND LAB,DEPT MOLEC BIOL,15601 CRABBS BRANCH WAY,ROCKVILLE,MD 20855

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.2644

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polypeptide growth factors act in part by inducing the expression of specific proteins that perform functions critical to cell cycle progression. We have used a differential display technique to identify genes that are expressed at higher levels following fibroblast growth factor (FGF)-1 (acidic FGF) stimulation of quiescent murine NIH 313 fibroblasts. Three such genes - liver (B-type) phosphofructokinase (PFK), fatty acid synthase (FAS) and sarco(endo)plasmic reticulum Ca2+-ATPase type 2 (SERCA2) - are described in this report. The level of FAS and SERCA2 mRNA expression is increased rapidly after FGF-1 addition; in contrast, PFK mRNA is induced with kinetics more typical of delayed-early genes. These results indicate that enhanced expression of the PFK, FAS and SERCA2 proteins may be important for FGF-1-stimulated cell proliferation. © 1993 Academic Press, Inc.

引用

页码：1483 / 1491

页数：9

共 43 条

[1] THE MITOGENIC RESPONSE TO TUMOR-NECROSIS-FACTOR ALPHA-REQUIRES C-JUN/AP-1 [J].

BRACH, MA ;

GRUSS, HJ ;

SOTT, C ;

HERRMANN, F .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (07) :4284-4290

[2] INCREASE OF THE GLYCOLYTIC RATE IN HUMAN RESTING FIBROBLASTS FOLLOWING SERUM STIMULATION - THE POSSIBLE ROLE OF THE FRUCTOSE-2,6-BISPHOSPHATE [J].

BRUNI, P ;

FARNARARO, M ;

VASTA, V ;

DALESSANDRO, A .

FEBS LETTERS, 1983, 159 (1-2) :39-42

[3] STRUCTURE-FUNCTION STUDIES OF HEPARIN-BINDING (ACIDIC FIBROBLAST) GROWTH FACTOR-I USING SITE-DIRECTED MUTAGENESIS [J].

BURGESS, WH ;

SHAHEEN, AM ;

HAMPTON, B ;

DONOHUE, PJ ;

WINKLES, JA .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1991, 45 (02) :131-138

[4] POSSIBLE DISSOCIATION OF THE HEPARIN-BINDING AND MITOGENIC ACTIVITIES OF HEPARIN-BINDING (ACIDIC FIBROBLAST) GROWTH FACTOR-I FROM ITS RECEPTOR-BINDING ACTIVITIES BY SITE-DIRECTED MUTAGENESIS OF A SINGLE LYSINE RESIDUE [J].

BURGESS, WH ;

SHAHEEN, AM ;

RAVERA, M ;

JAYE, M ;

DONOHUE, PJ ;

WINKLES, JA .

JOURNAL OF CELL BIOLOGY, 1990, 111 (05) :2129-2138

[5]

BURGESS WH, 1993, IN PRESS REGULATION

[6] A GENE ENCODING A PROTEIN WITH ZINC FINGERS IS ACTIVATED DURING G0/G1 TRANSITION IN CULTURED-CELLS [J].

CHAVRIER, P ;

ZERIAL, M ;

LEMAIRE, P ;

ALMENDRAL, J ;

BRAVO, R ;

CHARNAY, P .

EMBO JOURNAL, 1988, 7 (01) :29-35

[7] A MULTIGENE FAMILY ENCODING SEVERAL FINGER STRUCTURES IS PRESENT AND DIFFERENTIALLY ACTIVE IN MAMMALIAN GENOMES [J].

CHOWDHURY, K ;

DEUTSCH, U ;

GRUSS, P .

CELL, 1987, 48 (05) :771-778

[8] GROWTH-FACTORS IN DEVELOPMENT, TRANSFORMATION, AND TUMORIGENESIS [J].

CROSS, M ;

DEXTER, TM .

CELL, 1991, 64 (02) :271-280

[9]

DIAMOND I, 1978, J BIOL CHEM, V253, P866

[10]

Dixon HBF, 1986, J BIOL CHEM, V261, P13

← 1 2 3 4 5 →