NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND APPENDICITIS IN PATIENTS AGED OVER 50 YEARS

被引:15
作者
CAMPBELL, KL [1 ]
DEBEAUX, AC [1 ]
机构
[1] UNIV ABERDEEN,DEPT SURG,ABERDEEN AB9 1FX,SCOTLAND
关键词
D O I
10.1002/bjs.1800790938
中图分类号
R61 [外科手术学];
学科分类号
摘要
In a retrospective study 84 patients aged greater-than-or-equal-to 50 years undergoing emergency appendicectomy were matched for age and sex with 84 randomly selected emergency admissions as controls. Of the former, 31 (37 per cent) were taking non-steroidal anti-inflammatory drugs (NSAIDs) at admission, compared with nine (11 percent) of the controls (P < 0.01). In the study group a suppression of the while cell count was identified on admission in those taking NSAIDs (mean 11.9 x 10(9) l-1) compared with those not (mean 14.8 x 10(9) l-1) (P = 0-007). This is the first reported association between appendicitis and NSAIDs. The relative risk by odds ratio was substantially increased at 6.5 (95 per cent confidence interval 2.1-8.8). An NSAID-related impairment of host defences leading to failure in the resolution of inflammatory episodes may explain this association. It is further postulated that the suppression of the white cell response may be a marker of such an effect.
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页码:967 / 968
页数:2
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