FUNCTIONAL ACTIVATION OF JAK1 AND JAK3 BY SELECTIVE ASSOCIATION WITH IL-2 RECEPTOR SUBUNITS

被引：548

作者：

MIYAZAKI, T ^{[1
]}

KAWAHARA, A ^{[1
]}

FUJII, H ^{[1
]}

NAKAGAWA, Y ^{[1
]}

MINAMI, Y ^{[1
]}

LIU, ZJ ^{[1
]}

OISHI, I ^{[1
]}

SILVENNOINEN, O ^{[1
]}

WITTHUHN, BA ^{[1
]}

IHLE, JN ^{[1
]}

TANIGUCHI, T ^{[1
]}

机构：

[1] ST JUDE CHILDRENS RES HOSP, DEPT BIOCHEM, MEMPHIS, TN 38101 USA

来源：

SCIENCE | 1994年 / 266卷 / 5187期

关键词：

D O I：

10.1126/science.7973659

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The interleukin-2 receptor (IL-2) consists of three subunits: the IL-2R alpha, IL-2R beta, and IL-2R gamma chains, the last of which is also used in the receptors for IL-4, IL-7, and IL-9. Stimulation with IL-2 induces the tyrosine phosphorylation and activation of the Janus kinases Jak1 and Jak3. Jak1 and Jak3 were found to be selectively associated with the ''serine-rich'' region of IL-2R beta and the carboxyl-terminal region of IL-2R gamma, respectively. Both regions were necessary for IL-2 signaling. Furthermore, Jak3-negative fibroblasts expressing reconstituted IL-2R became responsive to IL-2 after the additional expression of Jak3 complementary DNA. Thus, activation of Jak1 and Jak3 may be a key event in IL-2 signaling.

引用

页码：1045 / 1047

页数：3

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