PRIMARY STRUCTURE AND DISTRIBUTION OF A NOVEL RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL FROM RABBIT BRAIN

被引：387

作者：

HAKAMATA, Y

NAKAI, J

TAKESHIMA, H

IMOTO, K

机构：

[1] Department of Medical Chemistry, Kyoto University Faculty of Medicine, Kyoto

来源：

FEBS LETTERS | 1992年 / 312卷 / 2-3期

关键词：

RYANODINE RECEPTOR; CALCIUM RELEASE CHANNEL; CDNA CLONING; RNA BLOT HYBRIDIZATION; SMOOTH MUSCLE; RABBIT BRAIN;

D O I：

10.1016/0014-5793(92)80941-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complete amino acid sequence of a novel ryanodine receptor/calcium release channel from rabbit brain has been deduced by cloning and sequence analysis of the cDNA. This protein is composed of 4872 amino acids and shares characteristic structural features with the skeletal muscle and cardiac ryanodine receptors. RNA blot hybridization analysis shows that the brain ryanodine receptor is abundantly expressed in corpus striatum, thalamus and hippocampus, whereas the cardiac ryanodine receptor is more uniformly expressed in the brain. The brain ryanodine receptor gene is transcribed also in smooth muscle.

引用

页码：229 / 235

页数：7

共 39 条

[1] ACTIVATION AND CONDUCTANCE PROPERTIES OF RYANODINE-SENSITIVE CALCIUM CHANNELS FROM BRAIN MICROSOMAL-MEMBRANES INCORPORATED INTO PLANAR LIPID BILAYERS [J].