MICROSATELLITE INSTABILITY IN CANCER OF THE PROXIMAL COLON

被引：2775

作者：

THIBODEAU, SN

BREN, G

SCHAID, D

机构：

[1] Molecular Genetics Laboratory, 970 Hilton Building, Mayo Clinic and Foundation, Rochester, MN 55905

来源：

SCIENCE | 1993年 / 260卷 / 5109期

关键词：

D O I：

10.1126/science.8484122

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Colorectal tumor DNA was examined for somatic instability at (CA)n repeats on human chromosomes 5q, 15q, 17p, and 18q. Differences between tumor and normal DNA were detected in 25 of the 90 (28 percent) tumors examined. This instability appeared as either a substantial change in repeat length (often heterogeneous in nature) or a minor change (typically two base pairs). Microsatellite instability was significantly correlated with the tumor's location in the proximal colon (P = 0.003), with increased patient survival (P = 0.02), and, inversely, with loss of heterozygosity for chromosomes 5q, 17p, and 18q. These data suggest that some colorectal cancers may arise through a mechanism that does not necessarily involve loss of heterozygosity.

引用

页码：816 / 819

页数：4

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