INDUCTION OF CD4+ HUMAN CYTOLYTIC T-CELLS SPECIFIC FOR HIV-INFECTED CELLS BY A GP160 SUBUNIT VACCINE

被引：177

作者：

ORENTAS, RJ

HILDRETH, JEK

OBAH, E

POLYDEFKIS, M

SMITH, GE

CLEMENTS, ML

SILICIANO, RF

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,CTR IMMUNIZAT RES,BALTIMORE,MD 21205

来源：

SCIENCE | 1990年 / 248卷 / 4960期

关键词：

D O I：

10.1126/science.2190315

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cytolytic T lymphocyte (CTL) responses were evaluated in humans immunized with recombinant human immunodeficiency virus type 1 (HIV) envelope glycoprotein gp160. Some vaccinees had gpl60-specific CTLs that were shown by cloning to be CD4+. Although induced by exogenous antigen, most gpl60-specific CTL clones also recognized gp160 synthesized endogenously in target cells. These clones lysed autologous CD4+ T lymphoblasts infected with HIV. Of particular interest were certain vaccine-induced clones that lysed HIV-infected cells, recognized gpl60 from diverse HIV isolates, and did not participate in "innocent bystander" killing of noninfected CD4+ T cells that had bound gpl20.

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页码：1234 / 1237

页数：4

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