DIADENOSINE POLYPHOSPHATES - THEIR BIOLOGICAL AND PHARMACOLOGICAL SIGNIFICANCE

被引：83

作者：

BAXI, MD ^{[1
]}

VISHWANATHA, JK ^{[1
]}

机构：

[1] UNIV NEBRASKA, MED CTR, DEPT BIOCHEM & MOLEC BIOL, OMAHA, NE 68198 USA

来源：

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS | 1995年 / 33卷 / 03期

关键词：

DINUCLEOSIDE POLYPHOSPHATE; DIADENOSINE POLYPHOSPHATE; AP(4)A;

D O I：

10.1016/1056-8719(94)00127-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that are ubiquitous in bacteria to mammals. In recent years, the diadenosine polyphosphates have received considerable attention in view of their multiple biological activities and potential pharmacological activities. Diadenosine polyphosphates have been identified as modulators of cardiovascular and neurotransmitter-like activities in recent years, besides their previously described role in cell proliferation and as signal molecules when cells are undergoing stress. Diadenosine polyphosphates and their synthetic analogues are being evaluated for their potential as pharmacological agents. This article discusses the various biological functions and physiological significance of the diadenosine polyphosphates.

引用

页码：121 / 128

页数：8

共 97 条

[61] IDENTIFICATION AND PARTIAL CHARACTERIZATION OF AN ADENOSINE(5')TETRAPHOSPHO(5')ADENOSINE HYDROLASE ON INTACT BOVINE AORTIC ENDOTHELIAL-CELLS [J].

OGILVIE, A ;

LUTHJE, J ;

POHL, U ;

BUSSE, R .

BIOCHEMICAL JOURNAL, 1989, 259 (01) :97-103

[62]

OGILVIE A, 1992, AP4A OTHER DINUCLEOS, P229

[63] THE ROLE OF ADENOSINE IN THE REGULATION OF GLOMERULAR-FILTRATION RATE AND RENIN SECRETION [J].

OSSWALD, H .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1984, 5 (03) :94-97

[64] INHIBITION OF TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE BY ADENINE DINUCLEOTIDES - UNIQUE INHIBITORY-ACTION OF AP5A [J].

PANDEY, VN ;

AMRUTE, SB ;

SATAV, JG ;

MODAK, MJ .

FEBS LETTERS, 1987, 213 (01) :204-208

[65]

PATON DM, 1988, ADENOSINE ADENINE NU

[66] METABOLISM OF ADENINE-NUCLEOTIDES BY ECTO-ENZYMES OF VASCULAR ENDOTHELIAL AND SMOOTH-MUSCLE CELLS IN CULTURE [J].

PEARSON, JD ;

CARLETON, JS ;

GORDON, JL .

BIOCHEMICAL JOURNAL, 1980, 190 (02) :421-429

[67] DIADENOSINE 5',5'''-P1,P4-TETRAPHOSPHATE(AP4A) LEVELS UNDER VARIOUS PROLIFERATIVE AND CYTOTOXIC CONDITIONS IN SEVERAL MAMMALIAN-CELL TYPES [J].

PERRET, J ;

HEPBURN, A ;

COCHAUX, P ;

VANSANDE, J ;

DUMONT, JE .

CELLULAR SIGNALLING, 1990, 2 (01) :57-65

[68]

PFEILSCHIFTER J, 1990, CELL SIGNAL, V2, P129

[69] PRESENCE OF DIADENOSINE POLYPHOSPHATES - AP4A AND AP5A - IN RAT-BRAIN SYNAPTIC TERMINALS - CA2+ DEPENDENT RELEASE EVOKED BY 4-AMINOPYRIDINE AND VERATRIDINE [J].

PINTOR, J ;

DIAZREY, MA ;

TORRES, M ;

MIRASPORTUGAL, MT .

NEUROSCIENCE LETTERS, 1992, 136 (02) :141-144

[70] CHARACTERIZATION AND QUANTIFICATION OF DIADENOSINE HEXAPHOSPHATE IN CHROMAFFIN CELLS - GRANULAR STORAGE AND SECRETAGOGUE-INDUCED RELEASE [J].

PINTOR, J ;

ROTLLAN, P ;

TORRES, M ;

MIRASPORTUGAL, MT .

ANALYTICAL BIOCHEMISTRY, 1992, 200 (02) :296-300

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