THE PRODUCT OF FEM-1, A NEMATODE SEX-DETERMINING GENE, CONTAINS A MOTIF FOUND IN CELL-CYCLE CONTROL PROTEINS AND RECEPTORS FOR CELL CELL-INTERACTIONS

被引：167

作者：

SPENCE, AM

COULSON, A

HODGKIN, J

机构：

[1] Cambridge, CB2 2QH England, MRC Laboratory Molecular Biology Hills Rd.

来源：

CELL | 1990年 / 60卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0092-8674(90)90346-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the cloning and sequencing of fem-1, a gene required for sex determination in both germline and somatic tissues in the nematode C. elegans. Clones carrying a 5.5 kb fragment are able to rescue the progeny of a fem-1 mutant when injected into its oocytes. The major fem-1 transcript in both sexes is 2.4 kb and comprises 11 exons. It encodes a soluble, intracellular protein of 656 amino acids that includes near its N-terminus six contiguous copies of a motif found in the products of the cdc10 gene of S. pombe, the SW16 gene of S. cerevisiae, the Notch gene of Drosophila, and the lin-12 and glp-1 genes of C. elegans. © 1990.

引用

页码：981 / 990

页数：10

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[1] CLONING, SEQUENCING AND TRANSCRIPTIONAL CONTROL OF THE SCHIZOSACCHAROMYCES-POMBE-CDC10 START GENE [J].