AFGF, BFGF AND FLG MESSENGER-RNAS SHOW DISTINCT PATTERNS OF INDUCTION IN THE HIPPOCAMPUS FOLLOWING KAINATE-INDUCED SEIZURES

被引：75

作者：

BUGRA, K ^{[1
]}

POLLARD, H ^{[1
]}

CHARTON, G ^{[1
]}

MOREAU, J ^{[1
]}

BENARI, Y ^{[1
]}

KHRESTCHATISKY, M ^{[1
]}

机构：

[1] INSERM,U29,F-75014 PARIS,FRANCE

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1994年 / 6卷 / 01期

关键词：

FIBROBLAST GROWTH FACTORS; FIBROBLAST GROWTH FACTOR RECEPTOR; KAINIC ACID; RT-PCR; IN SITU HYBRIDIZATION; RAT;

D O I：

10.1111/j.1460-9568.1994.tb00247.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report that kainic acid-induced seizures lead to marked increases in mRNAs encoding basic and acidic fibroblast growth factors (bFGF and aFGF, respectively) and flg, one of their receptors, in the rat hippocampus. Anticonvulsant pretreatment inhibits the up-regulation of these mRNAs. The observed increase in flg mRNA levels involves the pyramidal cells of all hippocampal subfietds and the granular cells of the dentate gyrus. The increased expression of aFGF and bFGF mRNAs is limited to neuron populations that are resistant to seizure-induced injury, the granular cells of dentate gyrus and pyramidal cells of CA1 region, respectively. The results suggest that the increase in the FGFs and flg may play pivotal roles in neuron survival and in long-term changes occurring in the hippocampus following seizure activity.

引用

收藏

页码：58 / 66

页数：9

相关论文

共 93 条

[21] PROMINENT EXPRESSION OF ACIDIC FIBROBLAST GROWTH-FACTOR IN MOTOR AND SENSORY NEURONS [J].

ELDE, R ;

CAO, Y ;

CINTRA, A ;

BRELJE, TC ;

PELTOHUIKKO, M ;

JUNTTILA, T ;

FUXE, K ;

PETTERSSON, RF ;

HOKFELT, T .

NEURON, 1991, 7 (03) :349-364

[22] Basic Fibroblast Growth Factor (FGF) in the Central Nervous System: Identification of Specific Loci of Basic FGF Expression in the Rat Brain [J].

Emoto, Naoya ;

Gonzalez, Ana-Maria ;

Walicke, Patricia A. ;

Wada, Etsuko ;

Simmons, Donna M. ;

Shimasaki, Shunichi ;

Baird, Andrew .

GROWTH FACTORS, 1989, 2 (01) :21-29

[23] INCREASED LEVELS OF MESSENGER-RNAS FOR NEUROTROPHIC FACTORS IN THE BRAIN DURING KINDLING EPILEPTOGENESIS [J].

ERNFORS, P ;

BENGZON, J ;

KOKAIA, Z ;

PERSSON, H ;

LINVALL, O .

NEURON, 1991, 7 (01) :165-176

[24] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

[25] LONG-TERM INCREASE OF GLUTAMATE-DECARBOXYLASE MESSENGER-RNA IN A RAT MODEL OF TEMPORAL-LOBE EPILEPSY [J].

FELDBLUM, S ;

ACKERMANN, RF ;

TOBIN, AJ .

NEURON, 1990, 5 (03) :361-371

[26] BASIC FIBROBLAST GROWTH FACTOR-INDUCED INCREASE IN ZIF/268 AND C-FOS MESSENGER-RNA LEVELS IS CA2+ DEPENDENT IN PRIMARY CULTURES OF HIPPOCAMPAL-NEURONS [J].

FERHAT, L ;

KHRESTCHATISKY, M ;

ROISIN, MP ;

BARBIN, G .

JOURNAL OF NEUROCHEMISTRY, 1993, 61 (03) :1105-1112

[27] LOCALIZATION OF BASIC FIBROBLAST GROWTH-FACTOR AND ITS MESSENGER-RNA AFTER CNS INJURY [J].

FRAUTSCHY, SA ;

WALICKE, PA ;

BAIRD, A .

BRAIN RESEARCH, 1991, 553 (02) :291-299

[28] LESION-INDUCED MOSSY FIBERS TO THE MOLECULAR LAYER OF THE RAT FASCIA DENTATA - IDENTIFICATION OF POSTSYNAPTIC GRANULE CELLS BY THE GOLGI-EM TECHNIQUE [J].

FROTSCHER, M ;

ZIMMER, J .

JOURNAL OF COMPARATIVE NEUROLOGY, 1983, 215 (03) :299-311

[29] KAINIC ACID-INDUCED SEIZURES STIMULATE INCREASED EXPRESSION OF NERVE GROWTH-FACTOR MESSENGER-RNA IN RAT HIPPOCAMPUS [J].

GALL, C ;

MURRAY, K ;

ISACKSON, PJ .

MOLECULAR BRAIN RESEARCH, 1991, 9 (1-2) :113-123

[30] LEVELS OF MESSENGER-RNA FOR A PUTATIVE KAINATE RECEPTOR ARE AFFECTED BY SEIZURES [J].

GALL, C ;

SUMIKAWA, K ;

LYNCH, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7643-7647

← 1 2 3 4 5 6 7 8 9 10 →