SITE-SPECIFIC, SUSTAINED-RELEASE OF DRUGS TO THE BRAIN

被引:180
作者
BODOR, N
FARAG, HH
BREWSTER, ME
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D O I
10.1126/science.7313698
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
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页码:1370 / 1372
页数:3
相关论文
共 11 条
[1]   DELIVERY OF A QUATERNARY PYRIDINIUM SALT ACROSS BLOOD-BRAIN-BARRIER BY ITS DIHYDROPYRIDINE DERIVATIVE [J].
BODOR, N ;
SHEK, E ;
HIGUCHI, T .
SCIENCE, 1975, 190 (4210) :155-156
[2]   ELIMINATION OF A QUATERNARY PYRIDINIUM SALT DELIVERED AS ITS DIHYDROPYRIDINE DERIVATIVE FROM BRAIN OF MICE [J].
BODOR, N ;
ROLLER, RG ;
SELK, SJ .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (05) :685-687
[3]   IMPROVED DELIVERY THROUGH BIOLOGICAL-MEMBRANES .1. SYNTHESIS AND PROPERTIES OF 1-METHYL-1,6-DIHYDROPYRIDINE-2-CARBALDOXIME, A PRO-DRUG OF N-METHYLPYRIDINIUM-2-CARBALDOXIME CHLORIDE [J].
BODOR, N ;
SHEK, E ;
HIGUCHI, T .
JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (01) :102-107
[4]   CONFORMATIONS, DNA BINDING PARAMETERS, AND ANTI-LEUKEMIC ACTIVITY OF CERTAIN CYTOTOXIC PROTOBERBERINE ALKALOIDS [J].
CUSHMAN, M ;
DEKOW, FW ;
JACOBSEN, LB .
JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (03) :331-333
[5]   CHEMISTRY OF DIHYDROPYRIDINES [J].
EISNER, U ;
KUTHAN, J .
CHEMICAL REVIEWS, 1972, 72 (01) :1-+
[6]  
GADAMER J, 1910, ARCH PHARM, V248, P670
[7]  
HOSHI A, 1976, GANN, V67, P321
[8]  
PANDRIDGE W, 1975, CRC CRITICAL REV TOX, P159
[9]   IMPROVED DELIVERY THROUGH BIOLOGICAL-MEMBRANES .3. DELIVERY OF N-METHYLPYRIDINIUM-2-CARBALDOXIME CHLORIDE THROUGH BLOOD-BRAIN-BARRIER IN ITS DIHYDROPYRIDINE PRO-DRUG FORM [J].
SHEK, E ;
HIGUCHI, T ;
BODOR, N .
JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (01) :113-117
[10]   IMPROVED DELIVERY THROUGH BIOLOGICAL-MEMBRANES .2. DISTRIBUTION, EXCRETION, AND METABOLISM OF N-METHYL-1,6-DIHYDROPYRIDINE-2-CARBALDOXIME HYDROCHLORIDE, A PRO-DRUG OF N-METHYLPYRIDINIUM-2-CARBALDOXIME CHLORIDE [J].
SHEK, E ;
HIGUCHI, T ;
BODOR, N .
JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (01) :108-112