ELIMINATION OF A QUATERNARY PYRIDINIUM SALT DELIVERED AS ITS DIHYDROPYRIDINE DERIVATIVE FROM BRAIN OF MICE

被引：26

作者：

BODOR, N

ROLLER, RG

SELK, SJ

机构：

[1] INTERx Research Corporation, Lawrence, Kansas

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1978年 / 67卷 / 05期

关键词：

Elimination rate—substituted quaternary pyridinium salt and prodrug from brain; mice; Prodrugs—dihydropyridine derivative of quaternary pyridinium salt; elimination rate from brain; Pyridinium salt; substituted quaternary—and prodrug;

D O I：

10.1002/jps.2600670531

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1‐Methylpyridine‐2‐carbaldehyde oxime, a quaternary pyridinium salt, can be delivered efficiently through the blood‐brain barrier in its dihydropyridine prodrug form. This redox system was used to study the elimination rate from the brain of a small quaternary salt. It was found that the oxime is eliminated relatively fast from the brain, which supports a hypothesis for the existence of an active transport mechanism for eliminating organic ions from the brain. The possibilities of using the pyridinium salt ⇌ dihydropyridine redox system for specific delivery of drugs to the brain are discussed. Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company

引用

页码：685 / 687

页数：3

共 13 条

[1] DELIVERY OF A QUATERNARY PYRIDINIUM SALT ACROSS BLOOD-BRAIN-BARRIER BY ITS DIHYDROPYRIDINE DERIVATIVE [J].