GENETIC-HETEROGENEITY OF THE HUMAN GLUTATHIONE TRANSFERASES - A COMPLEX OF GENE FAMILIES

被引：252

作者：

BOARD, P ^{[1
]}

COGGAN, M ^{[1
]}

JOHNSTON, P ^{[1
]}

ROSS, V ^{[1
]}

SUZUKI, T ^{[1
]}

WEBB, G ^{[1
]}

机构：

[1] QUEEN ELIZABETH HOSP, DEPT GENET, ADELAIDE, SA, AUSTRALIA

来源：

PHARMACOLOGY & THERAPEUTICS | 1990年 / 48卷 / 03期

关键词：

D O I：

10.1016/0163-7258(90)90054-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The glutathione transferases (GSTs) are involved in the metabolism of a wide range of compounds of both exogenous and endogenous origin. There is evidence that deficiency of GST may increase sensitivity to certain environmentally derived carcinogens. In contrast, elevated expression has been implicated in resistance to therapeutic drugs. The GSTs are the products of several gene families. This review summarizes the present knowledge of the genetic interrelationship between the various isoenzymes, their deficiencies and the physical locations of their genes.

引用

页码：357 / 369

页数：13

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