GENETIC-HETEROGENEITY OF THE HUMAN GLUTATHIONE TRANSFERASES - A COMPLEX OF GENE FAMILIES

被引:252
作者
BOARD, P [1 ]
COGGAN, M [1 ]
JOHNSTON, P [1 ]
ROSS, V [1 ]
SUZUKI, T [1 ]
WEBB, G [1 ]
机构
[1] QUEEN ELIZABETH HOSP, DEPT GENET, ADELAIDE, SA, AUSTRALIA
关键词
D O I
10.1016/0163-7258(90)90054-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The glutathione transferases (GSTs) are involved in the metabolism of a wide range of compounds of both exogenous and endogenous origin. There is evidence that deficiency of GST may increase sensitivity to certain environmentally derived carcinogens. In contrast, elevated expression has been implicated in resistance to therapeutic drugs. The GSTs are the products of several gene families. This review summarizes the present knowledge of the genetic interrelationship between the various isoenzymes, their deficiencies and the physical locations of their genes.
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收藏
页码:357 / 369
页数:13
相关论文
共 88 条
[11]   ISOLATION OF A CDNA CLONE AND LOCALIZATION OF HUMAN GLUTATHIONE S-TRANSFERASE-2 GENES TO CHROMOSOME BAND 6P12 [J].
BOARD, PG ;
WEBB, GC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2377-2381
[13]   HUMAN-MUSCLE GLUTATHIONE S-TRANSFERASE (GST-4) SHOWS CLOSE HOMOLOGY TO HUMAN-LIVER GST-1 [J].
BOARD, PG ;
SUZUKI, T ;
SHAW, DC .
BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 953 (03) :214-217
[14]   EXPRESSION OF HUMAN GLUTATHIONE S-TRANSFERASE-2 IN ESCHERICHIA-COLI - IMMUNOLOGICAL COMPARISON WITH THE BASIC GLUTATHIONE S-TRANSFERASES ISOENZYMES FROM HUMAN-LIVER [J].
BOARD, PG ;
PIERCE, K .
BIOCHEMICAL JOURNAL, 1987, 248 (03) :937-941
[16]   AN ENZYME FROM RAT LIVER CATALYSING CONJUGATIONS WITH GLUTATHIONE [J].
BOOTH, J ;
BOYLAND, E ;
SIMS, P .
BIOCHEMICAL JOURNAL, 1961, 79 (03) :516-&
[17]   METABOLISM OF ETHANOL AND CARCINOGENS BY GLUTATHIONE TRANSFERASES [J].
BORA, PS ;
SPILBURG, CA ;
LANGE, LG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) :4470-4473
[18]  
BOYLAND E, 1969, ADV ENZYMOL RAMB, V32, P173
[19]  
BULLER AL, 1987, MOL PHARMACOL, V31, P575
[20]   AMINO-ACID SUBSTITUTIONS IN THE HUMAN GLUTATHIONE S-TRANSFERASES CONFER DIFFERENT SPECIFICITIES IN THE PROSTAGLANDIN ENDOPEROXIDE CONVERSION PATHWAY [J].
BURGESS, JR ;
CHOW, NWI ;
REDDY, CC ;
TU, CPD .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 158 (02) :497-502