SKN-1A AND SKN-1I - 2 FUNCTIONALLY DISTINCT OCT-2-RELATED FACTORS EXPRESSED IN EPIDERMIS

被引：108

作者：

ANDERSEN, B ^{[1
]}

SCHONEMANN, MD ^{[1
]}

FLYNN, SE ^{[1
]}

PEARSE, RV ^{[1
]}

SINGH, H ^{[1
]}

ROSENFELD, MG ^{[1
]}

机构：

[1] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637

来源：

SCIENCE | 1993年 / 260卷 / 5104期

关键词：

D O I：

10.1126/science.7682011

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two forms of a member of the POU domain family of transcriptional regulators, highly related to Oct-2, are selectively expressed in terminally differentiating epidermis and hair follicles. One form, referred to as Skn-1i, contains an amino-terminal domain that inhibits DNA binding and can inhibit transactivation by Oct-1. A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression. The pattern of expression of the Skn-1a/i gene products and the effect of the alternative products on the expression of other genes suggest that these factors serve regulatory functions with respect to epidermal development.

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页码：78 / 82

页数：5

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