THE MATRIX-DEGRADING METALLOPROTEINASES

被引：1332

作者：

MATRISIAN, LM

机构：

[1] Dept of Cell Biology, Vanderbilt University, Nashville, Tennessee

来源：

BIOESSAYS | 1992年 / 14卷 / 07期

关键词：

D O I：

10.1002/bies.950140705

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The matrix-degrading metalloproteinases are an intriguing family of enzymes that have evolved to digest specific extracellular matrix components. The expression of these enzymes is very highly regulated and can be controlled transcriptionally by a number of growth factors, tumor promoters, oncogenes, and hormones. It is suggested that the coordinated regulation of matrix metalloproteinases and their inhibitors by these agents modify the integrity of the extracellular matrix. These modifications may, at least in part, be responsible for mediating the effects of these factors on complex physiological processes.

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页码：455 / 463

页数：9

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