DEVELOPMENT AND CLINICAL-TESTING OF AN ACELLULAR PERTUSSIS-VACCINE CONTAINING GENETICALLY DETOXIFIED PERTUSSIS TOXIN

被引：8

作者：

RAPPUOLI, R

PIZZA, M

DEMAGISTRIS, MT

PODDA, A

BUGNOLI, M

MANETTI, R

NENCIONI, L

机构：

[1] Sclavo Research Center, Siena

来源：

IMMUNOBIOLOGY | 1992年 / 184卷 / 2-3期

关键词：

D O I：

10.1016/S0171-2985(11)80477-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 1924 RAMON described the inactivation of diphtheria toxin by formaldehyde treatment. This method allowed the introduction of mass vaccination against diphtheria and tetanus and opened the way to the inactivation of viruses by chemical treatment. In this review we describe the use of genetic manipulations for the inactivation of pertussis toxin. The toxin inactivated by this new method is an antigen superior to those obtained by chemical treatment and has been used to develop a new vaccine against whooping cough.

引用

页码：230 / 239

页数：10

共 33 条

[21] MUTANTS OF PERTUSSIS TOXIN SUITABLE FOR VACCINE DEVELOPMENT [J].

PIZZA, M ;

COVACCI, A ;

BARTOLONI, A ;

PERUGINI, M ;

NENCIONI, L ;

DEMAGISTRIS, MT ;

VILLA, L ;

NUCCI, D ;

MANETTI, R ;

BUGNOLI, M ;

GIOVANNONI, F ;

OLIVIERI, R ;

BARBIERI, JT ;

SATO, H ;

RAPPUOLI, R .

SCIENCE, 1989, 246 (4929) :497-500

[22] SUBUNIT-S1 OF PERTUSSIS TOXIN - MAPPING OF THE REGIONS ESSENTIAL FOR ADP-RIBOSYLTRANSFERASE ACTIVITY [J].

PIZZA, M ;

BARTOLONI, A ;

PRUGNOLA, A ;

SILVESTRI, S ;

RAPPUOLI, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (20) :7521-7525

[23] METABOLIC, HUMORAL, AND CELLULAR-RESPONSES IN ADULT VOLUNTEERS IMMUNIZED WITH THE GENETICALLY INACTIVATED PERTUSSIS TOXIN MUTANT PT-9K/129G [J].

PODDA, A ;

NENCIONI, L ;

DEMAGISTRIS, MT ;

DITOMMASO, A ;

BOSSU, P ;

NUTI, S ;

PILERI, P ;

PEPPOLONI, S ;

BUGNOLI, M ;

RUGGIERO, P ;

MARSILI, I ;

DERRICO, A ;

TAGLIABUE, A ;

RAPPUOLI, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (03) :861-868

[24] PHASE-I CLINICAL-TRIAL OF AN ACELLULAR PERTUSSIS-VACCINE COMPOSED OF GENETICALLY DETOXIFIED PERTUSSIS TOXIN COMBINED WITH FHA AND 69-KDA [J].

PODDA, A ;

NENCIONI, L ;

MARSILI, I ;

PEPPOLONI, S ;

VOLPINI, G ;

DONATI, D ;

DITOMMASO, A ;

DEMAGISTRIS, MT ;

RAPPUOLI, R .

VACCINE, 1991, 9 (10) :741-745

[25]

PODDA A, 1991, UNPUB J PEDIATRICS

[26]

Ramon G., 1924, ANN I PASTEUR PARIS, V38, P1

[27]

SATO Y, 1984, LANCET, V1, P122

[28] CLINICAL, METABOLIC, AND ANTIBODY-RESPONSES OF ADULT VOLUNTEERS TO AN INVESTIGATIONAL VACCINE COMPOSED OF PERTUSSIS TOXIN INACTIVATED BY HYDROGEN-PEROXIDE [J].

SEKURA, RD ;

ZHANG, YL ;

ROBERSON, R ;

ACTON, B ;

TROLLFORS, B ;

TOLSON, N ;

SHILOACH, J ;

BRYLA, D ;

MUIRNASH, J ;

KOELLER, D ;

SCHNEERSON, R ;

ROBBINS, JB .

JOURNAL OF PEDIATRICS, 1988, 113 (05) :806-813

[29] MORTALITY AND MORBIDITY FROM INVASIVE BACTERIAL-INFECTIONS DURING A CLINICAL-TRIAL OF ACELLULAR PERTUSSIS VACCINES IN SWEDEN [J].

STORSAETER, J ;

OLIN, P ;

RENEMAR, B ;

LAGERGARD, T ;

NORBERG, R ;

ROMANUS, V ;

TIRU, M .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1988, 7 (09) :637-645

[30] SECONDARY ANALYSES OF THE EFFICACY OF 2 ACELLULAR PERTUSSIS VACCINES EVALUATED IN A SWEDISH PHASE-III TRIAL [J].

STORSAETER, J ;

HALLANDER, H ;

FARRINGTON, CP ;

OLIN, P ;

MOLLBY, R ;

MILLER, E .

VACCINE, 1990, 8 (05) :457-461

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