SIGNAL CONVERGENCE ON PROTEIN KINASE-A AS A MOLECULAR CORRELATE OF LEARNING

被引：38

作者：

ASZODI, A ^{[1
]}

MULLER, U ^{[1
]}

FRIEDRICH, P ^{[1
]}

SPATZ, HC ^{[1
]}

机构：

[1] UNIV FREIBURG,INST BIOL 3,W-7800 FREIBURG,GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 13期

关键词：

PHOSPHORYLATION; CA2+-DEPENDENT PROTEOLYTIC MODIFICATION; ACQUISITION; CONTIGUITY; MEMORY;

D O I：

10.1073/pnas.88.13.5832

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The response of a reaction network composed of protein kinase A, calpain, and protein phosphatase to transient cAMP and Ca2+ signals was studied. An essential feature of signal convergence is that the regulatory subunit of cAMP-dissociated protein kinase A undergoes limited proteolysis by the Ca2+-activated proteinase calpain. A dynamic model of this system based on kinetic differential equations was built and simulated by computer. The system shows analogies to typical features of associative learning such as acquisition, contiguity detection, extinction, and memory decay, suggesting that these biochemical reactions may be part of the molecular mechanism of learning in Drosophila.

引用

页码：5832 / 5836

页数：5

共 46 条

[1] IS CONTIGUITY DETECTION IN CLASSICAL-CONDITIONING A SYSTEM OR A CELLULAR PROPERTY - LEARNING IN APLYSIA SUGGESTS A POSSIBLE MOLECULAR SITE [J].