IMMUNE-COMPLEXES IN RHEUMATOID-ARTHRITIS SERA AND SYNOVIAL-FLUIDS - COMPARISON OF 3 METHODS

被引：86

作者：

HALLA, JT ^{[1
]}

VOLANAKIS, JE ^{[1
]}

SCHROHENLOHER, RE ^{[1
]}

机构：

[1] UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35294

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 05期

关键词：

D O I：

10.1002/art.1780220502

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sera and synovial fluids from 88 patients with rheumatoid arthritis were examined for circulating immune complexes by three assays: monoclonal rheumatoid factor radioimmunoassay, Clq binding assay, and Raji cell radioassay. Paired samples were available for 82 patients. Immune complexes were detected with high frequency in the synovial fluid by each assay (75% by the monoclonal rheumatoid factor radioimmunoassay, 95% by the Clq binding assay, and 61% by the Raji cell radioassay). In rheumatoid arthritis sera, immune complexes were detected with high frequency by the Clq binding assay (85%) and the monoclonal rheumatoid factor radioimmunoassay (70%) but infrequently by the Raji cell radioassay (26%). The presence of immune complexes in serum was most frequently accompanied by the presence of complexes in fluid, regardless of the method of detection; moreover, the levels of immune complexes in synovial fluid were generally higher than in paired serum. Further, the levels of immune complexes as measured by the Clq binding assay correlated with certain parameters of clinical activity, while the monoclonal rheumatoid factor radioimmunoassay and Raji cell radioassay correlated with extraarticular features (excluding nodules) of rheumatoid arthritis. Copyright © 1979 American College of Rheumatology

引用

页码：440 / 448

页数：9

共 27 条

[21] BINDING OF SOLUBLE IMMUNE-COMPLEXES TO HUMAN LYMPHOBLASTOID CELLS .2. USE OF RAJI CELLS TO DETECT CIRCULATING IMMUNE-COMPLEXES IN ANIMAL AND HUMAN SERA [J].