LONG-TERM POTENTIATION AS SYNAPTIC DIALOG

被引：121

作者：

COLLEY, PA ^{[1
]}

ROUTTENBERG, A ^{[1
]}

机构：

[1] NORTHWESTERN UNIV, CRESAP NEUROSCI LAB, 2021 SHERIDAN RD, RM 311, EVANSTON, IL 60208 USA

来源：

BRAIN RESEARCH REVIEWS | 1993年 / 18卷 / 01期

关键词：

HIPPOCAMPUS; PROTEIN KINASE-C; TRANSSYNAPTIC SIGNALING; LONG-TERM POTENTIATION;

D O I：

10.1016/0165-0173(93)90009-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have proposed a testable model of the physiological and biochemical events underlying LTP that offers the following novel features. (1) The focus is not on a single mechanism or synaptic site, but rather on the integration and interaction of mechanisms occurring on both sides of the synapse. (2) beta PKC plays a critical presynaptic role in LTP, while gamma PKC functions postsynaptically. (3) These stages can be ordered in a time-delimited sequence of post- then presynaptic molecular events based on the period of effectiveness of inhibitor compounds. (4) The distinction is made between the time when kinase activation occurs and the time when the potentiated response requiring this kinase activation is observed.

引用

页码：115 / 122

页数：8

共 103 条

[41] NMDA RECEPTOR BLOCKADE PREVENTS THE INCREASE IN PROTEIN KINASE-C SUBSTRATE (PROTEIN-F1) PHOSPHORYLATION PRODUCED BY LONG-TERM POTENTIATION [J].

LINDEN, DJ ;

WONG, KL ;

SHEU, FS ;

ROUTTENBERG, A .

BRAIN RESEARCH, 1988, 458 (01) :142-146

[42] A NEWLY DISCOVERED PROTEIN-KINASE-C ACTIVATOR (OLEIC-ACID) ENHANCES LONG-TERM POTENTIATION IN THE INTACT HIPPOCAMPUS [J].

LINDEN, DJ ;

MURAKAMI, K ;

ROUTTENBERG, A .

BRAIN RESEARCH, 1986, 379 (02) :358-363

[43]

LINDEN DJ, 1987, J NEUROSCI, V7, P3783

[44] PROTEIN-KINASE-C INHIBITORS ELIMINATE HIPPOCAMPAL LONG-TERM POTENTIATION [J].

LOVINGER, DM ;

WONG, KL ;

MURAKAMI, K ;

ROUTTENBERG, A .

BRAIN RESEARCH, 1987, 436 (01) :177-183

[45] SYNAPSE-SPECIFIC PROTEIN KINASE-C ACTIVATION ENHANCES MAINTENANCE OF LONG-TERM POTENTIATION IN RAT HIPPOCAMPUS [J].

LOVINGER, DM ;

ROUTTENBERG, A .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 400 :321-333

[46] DIRECT RELATION OF LONG-TERM SYNAPTIC POTENTIATION TO PHOSPHORYLATION OF MEMBRANE-PROTEIN F1, A SUBSTRATE FOR MEMBRANE KINASE-C [J].

LOVINGER, DM ;

COLLEY, PA ;

AKERS, RF ;

NELSON, RB ;

ROUTTENBERG, A .

BRAIN RESEARCH, 1986, 399 (02) :205-211

[47] A SELECTIVE INCREASE IN PHOSPORYLATION OF PROTEIN-FI, A PROTEIN-KINASE C SUBSTRATE, DIRECTLY RELATED TO 3 DAY GROWTH OF LONG-TERM SYNAPTIC ENHANCEMENT [J].

LOVINGER, DM ;

AKERS, RF ;

NELSON, RB ;

BARNES, CA ;

MCNAUGHTON, BL ;

ROUTTENBERG, A .

BRAIN RESEARCH, 1985, 343 (01) :137-143

[48] THE BIOCHEMISTRY OF MEMORY - A NEW AND SPECIFIC HYPOTHESIS [J].

LYNCH, G ;

BAUDRY, M .

SCIENCE, 1984, 224 (4653) :1057-1063

[49] INTRACELLULAR INJECTIONS OF EGTA BLOCK INDUCTION OF HIPPOCAMPAL LONG-TERM POTENTIATION [J].

LYNCH, G ;

LARSON, J ;

KELSO, S ;

BARRIONUEVO, G ;

SCHOTTLER, F .

NATURE, 1983, 305 (5936) :719-721

[50] LONG-TERM POTENTIATION OF SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS OF THE RAT - EFFECT OF CALMODULIN AND OLEOYL-ACETYL-GLYCEROL ON RELEASE OF [H-3] GLUTAMATE [J].

LYNCH, MA ;

BLISS, TVP .

NEUROSCIENCE LETTERS, 1986, 65 (02) :171-176

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