SPONTANEOUS-ABORTION RATE AND ADVANCED MATERNAL AGE - CONSEQUENCES FOR PRENATAL-DIAGNOSIS

被引：33

作者：

COHENOVERBEEK, TE ^{[1
]}

HOP, WCJ ^{[1
]}

DENOUDEN, M ^{[1
]}

PIJPERS, L ^{[1
]}

JAHODA, MGJ ^{[1
]}

WLADIMIROFF, JW ^{[1
]}

机构：

[1] ERASMUS UNIV, SCH MED, DEPT EPIDEMIOL & BIOSTAT, 3000 DR ROTTERDAM, NETHERLANDS

来源：

LANCET | 1990年 / 336卷 / 8706期

关键词：

D O I：

10.1016/0140-6736(90)91528-I

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Maternal age related and procedure-related fetal abortion rates were studied in 384 women aged 36 and over scheduled for transabdominal chorionic villus sampling (TA-CVS) at 12-14 weeks of gestation. The pre-TA-CVS abortion rate within 30 days of intake (at 6-10 weeks of gestation) rose from 1·9% at age 35-36 years to 10·9% at 40 years and older. Women entering in the 6th week of gestation had a greater probability of aborting before TA-CVS than women entering after day 48. 26 women aborted spontaneously before TA-CVS, the majority of abortions occuring at 10-12 weeks. TA-CVS was done in 346 women. 11 pregnancies were terminated because of genetic anomalies, and 8 women had spontaneous fetal loss. These findings justify delaying prenatal diagnosis in older pregnant women until 12 weeks of gestation. © 1990.

引用

页码：27 / 29

页数：3

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