EFFICACY OF A MONOCLONAL-ANTIBODY DIRECTED AGAINST TUMOR-NECROSIS-FACTOR IN PROTECTING NEUTROPENIC RATS FROM LETHAL INFECTION WITH PSEUDOMONAS-AERUGINOSA

被引：93

作者：

OPAL, SM

CROSS, AS

KELLY, NM

SADOFF, JC

BODMER, MW

PALARDY, JE

VICTOR, GH

机构：

[1] BROWN UNIV,PROGRAM MED,PROVIDENCE,RI 02912

[2] WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307

[3] CELLTECH LTD,SLOUGH,ENGLAND

来源：

JOURNAL OF INFECTIOUS DISEASES | 1990年 / 161卷 / 06期

关键词：

D O I：

10.1093/infdis/161.6.1148

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A monoclonal antibody directed against murine tumor necrosis factor- (TNF) was studied in a neutropenic rat model to determine its efficacy in protecting animals from lethal infection with Pseudomonas aeruginosa. Anti-TNF monoclonal antibody at a dose of 20 mg/kg given intravenously at 0 and 120 h resulted in a 53% survival rate (8/15) compared with no survival in control animals (0/15) (P <.(05). The combination of anti-TNF monoclonal antibody and oral ciprofloxacin at a suboptimal dose of 2.5 mg/kg/day resulted in a 100% survival rate in neutropenic animals (16/16), while ciprofloxacin alone produced only, a 67% survival rate (10/15) during the 7-day period of neutropenia (P <.05). Thus anti-TNF monoclonal antibody alone or in addition to antimicrobial agents improved survival in neutropenic animals after infection with P. oeruginosa. © 1990, University of Chicago. All rights reserved.

引用

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页码：1148 / 1152

页数：5

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