EFFECT OF CRYSTAL FORM CORTISONE ALCOHOL AND AGITATION ON CRYSTAL GROWTH OF CORTISONE ACETATE IN AQUEOUS SUSPENSIONS

被引：26

作者：

CARLESS, JE

MOUSTAFA, MA

RAPSON, HDC

机构：

[1] Department of Pharmacy, Chelsea College of Science and Technology (University of London), London, SW3, Manresa Road

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1968年 / 20卷 / 08期

关键词：

D O I：

10.1111/j.2042-7158.1968.tb09826.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Particle size distribution in aqueous suspensions of stable and unstable crystal forms of cortisone acetate under conditions of agitation and different degrees of saturation with cortisone alcohol is described. Agitation accelerated the diffusion‐controlled processes of dissolution and crystallization, leading to the formation of a high proportion of large particles. Cortisone alcohol inhibited the polymorphic transformation necessary for the crystal growth and formation of the water‐stable form. The mechanism of action is discussed. 1968 Royal Pharmaceutical Society of Great Britain

引用

页码：639 / &

共 7 条

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