RNA SEQUENCE AND THE NATURE OF THE CUA-BINDING SITE IN CYTOCHROME-C-OXIDASE

被引：41

作者：

COVELLO, PS ^{[1
]}

GRAY, MW ^{[1
]}

机构：

[1] DALHOUSIE UNIV, DEPT BIOCHEM, HALIFAX B3H 4H7, NS, CANADA

来源：

FEBS LETTERS | 1990年 / 268卷 / 01期

关键词：

Copper binding site; Cytochrome c oxidase; RNA editing;

D O I：

10.1016/0014-5793(90)80958-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For cytochrome c oxidase subunit II (COXII), DNA and protein sequences suggest that Met-207 (bovine numbering) is conserved in all species except plants. Sequencing of plant mitochondrial COXII mRNAs now indicates that Met-207 is also conserved among plants as a result of a C-to-U type of RNA editing. Considering the strict evolutionary conservation of Met-207 and the homology of COXII to type I (blue) copper proteins and nitrous oxide reductase, we propose a model in which Met-207 is associated with the CuA-binding site (along with Cys-196, Cys-200 and His-204) and plays a role in determining its reduction potential and stability. © 1990.

引用

页码：5 / 7

页数：3

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