ROLE OF SUPEROXIDE ANION IN XANTHINE OXIDASE-INDUCED AUTOXIDATION OF LINOLEIC-ACID

被引：87

作者：

THOMAS, MJ ^{[1
]}

MEHL, KS ^{[1
]}

PRYOR, WA ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV,DEPT CHEM,BATON ROUGE,LA 70803

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 83卷 / 03期

关键词：

D O I：

10.1016/0006-291X(78)91484-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The superoxide anion-radical (O2•) is an intermediate in the xanthine oxidase catalyzed autoxidation of linoleic acid. We have now found, however, that the rate of the xanthine oxidase catalyzed autoxidation of linoleic acid depends upon the initial concentration of conjugated diene hydroperoxide, the autoxidation product of linoleic acid. We propose that the reaction of diene hydroperoxide with O2• produces alkoxy radicals that then initiate autoxidation. The rate constant for the diene hydroperoxide-O2• reaction is 7 × 103 M-1 s-1. © 1978.

引用

页码：927 / 932

页数：6

共 19 条

[1]

BEAUCHAMP C, 1970, J BIOL CHEM, V245, P4641

[2] The interaction of ozone and hydrogen peroxide in aqueous solution [J].