CHARACTERIZATION OF A GASTRIN RELEASING PEPTIDE FROM PORCINE NON-ANTRAL GASTRIC TISSUE

被引：858

作者：

MCDONALD, TJ

JORNVALL, H

NILSSON, G

VAGNE, M

GHATEI, M

BLOOM, SR

MUTT, V

机构：

[1] ROYAL POSTGRAD MED SCH, DEPT MED, LONDON W12 0HS, ENGLAND

[2] SWEDISH UNIV AGR SCI, FAC VET MED, DEPT PHYSIOL, S-75007 UPPSALA, SWEDEN

[3] KAROLINSKA INST, DEPT CHEM 1, S-10401 STOCKHOLM 60, SWEDEN

[4] KAROLINSKA INST, DEPT BIOCHEM 2, S-10401 STOCKHOLM 60, SWEDEN

[5] HOP HERRIOT, INSERM U45, LYON, FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)91614-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A heptacosapeptide with potent gastrin releasing activity has been isolated from porcine non-antral gastric and intestinal tissue. The amino acid sequence suggested from a preliminary study on the gastric peptide is: Ala-Pro-Val-Ser-Val-Gly-Gly-Gly-Thr-Val-Leu-Ala-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2. Striking homology in the C-terminal region is seen with bombesin, accounting for the similar bioactivities of the two peptides. Some structural resemblance with porcine cholecystokinin in the N-terminal region is noted. © 1979.

引用

页码：227 / 233

页数：7

共 23 条

[1] ISOLATION AND STRUCTURE OF BOMBESIN AND ALYTESIN, 2 ANALOGOUS ACTIVE PEPTIDES FROM SKIN OF EUROPEAN AMPHIBIANS BOMBINA AND ALYTES [J].