AUTOLOGOUS NEUTRALIZING ANTIBODIES PREVAIL IN HIV-2 BUT NOT IN HIV-1 INFECTION

被引：74

作者：

BJORLING, E

SCARLATTI, G

VONGEGERFELT, A

ALBERT, J

BIBERFELD, G

CHIODI, F

NORRBY, E

FENYO, EM

机构：

[1] KAROLINSKA INST, DEPT VIROL, S-10521 STOCKHOLM, SWEDEN

[2] NATL BACTERIOL LAB, DEPT VIROL, S-10521 STOCKHOLM, SWEDEN

[3] NATL BACTERIOL LAB, DEPT IMMUNOL, S-10521 STOCKHOLM, SWEDEN

来源：

VIROLOGY | 1993年 / 193卷 / 01期

关键词：

D O I：

10.1006/viro.1993.1160

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus type 2 (HIV-2) has been reported to be less pathogenic than HIV-1. We have investigated the capacity of sera from nine HIV-2-infected individuals to neutralize their own autologous virus. All nine HIV-2-infected individuals neutralized autologous virus with titers ranging between 20 and 320. In contrast, we have previously reported that most HIV-1-infected individuals lack such antibodies. The difference between HIV-1 and HIV-2 infection was statistically significant (P < 0.0002, Pearson test) and the difference in neutralizing antibody prevalence may explain the faster disease progression in HIV-1-infected individuals than in HIV-2-infected individuals. © 1993 Academic Press, Inc.

引用

页码：528 / 530

页数：3

共 22 条

[1] RAPID DEVELOPMENT OF ISOLATE-SPECIFIC NEUTRALIZING ANTIBODIES AFTER PRIMARY HIV-1 INFECTION AND CONSEQUENT EMERGENCE OF VIRUS VARIANTS WHICH RESIST NEUTRALIZATION BY AUTOLOGOUS SERA [J].