ACTIVATED T-CELLS INDUCED INTERLEUKIN-12 PRODUCTION BY MONOCYTES VIA CD40-CD40 LIGAND INTERACTION

被引：401

作者：

SHU, U

KINIWA, M

WU, CY

MALISZEWSKI, C

VEZZIO, N

HAKIMI, J

GATELY, M

DELESPESSE, G

机构：

[1] UNIV MONTREAL,NOTRE DAME HOSP,RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA

[2] IMMUNEX RES & DEV CORP,SEATTLE,WA 98101

[3] HOFFMANN LA ROCHE INC,NUTLEY,NJ 07110

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1995年 / 25卷 / 04期

关键词：

CD40-CD40 LIGAND INTERACTION; MONOCYTES; INTERLEUKIN-12; PRODUCTION;

D O I：

10.1002/eji.1830250442

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous studies on the production of interleukin-12 (IL-12) have shown that it is released, together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a variety of pathogens. We here report that IL-12 is also released during the recall response to soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells induce the production of IL-12 by monocytes via a mechanism involving the interaction of T cell-associated CD40 ligand with CD40 on monocytes. The data suggest that Ag presentation on monocytes favors the persistence of type 1 responses.

引用

收藏

页码：1125 / 1128

页数：4

相关论文

共 21 条

[1] CD40 EXPRESSION BY HUMAN MONOCYTES - REGULATION BY CYTOKINES AND ACTIVATION OF MONOCYTES BY THE LIGAND FOR CD40 [J].

ALDERSON, MR ;

ARMITAGE, RJ ;

TOUGH, TW ;

STROCKBINE, L ;

FANSLOW, WC ;

SPRIGGS, MK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :669-674

[2] INTERFERON-GAMMA INHIBITS INTERLEUKIN-10 PRODUCTION BY MONOCYTES [J].

CHOMARAT, P ;

RISSOAN, MC ;

BANCHEREAU, J ;

MIOSSEC, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :523-527

[3] INTERLEUKIN-10 (IL-10) INHIBITS HUMAN LYMPHOCYTE INTERFERON GAMMA-PRODUCTION BY SUPPRESSING NATURAL-KILLER-CELL STIMULATORY FACTOR/IL-12 SYNTHESIS IN ACCESSORY CELLS [J].

DANDREA, A ;

ASTEAMEZAGA, M ;

VALIANTE, NM ;

MA, XJ ;

KUBIN, M ;

TRINCHIERI, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) :1041-1048

[4] PRODUCTION OF NATURAL-KILLER-CELL STIMULATORY FACTOR (INTERLEUKIN-12) BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS [J].

DANDREA, A ;

RENGARAJU, M ;

VALIANTE, NM ;

CHEHIMI, J ;

KUBIN, M ;

ASTE, M ;

CHAN, SH ;

KOBAYASHI, M ;

YOUNG, D ;

NICKBARG, E ;

CHIZZONITE, R ;

WOLF, SF ;

TRINCHIERI, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) :1387-1398

[5]

FANSLOW WC, 1992, J IMMUNOL, V149, P655

[6]

FIORENTINO DF, 1991, J IMMUNOL, V146, P3444

[7] ADMINISTRATION OF RECOMBINANT IL-12 TO NORMAL MICE ENHANCES CYTOLYTIC LYMPHOCYTE ACTIVITY AND INDUCES PRODUCTION OF IFN-GAMMA IN-VIVO [J].

GATELY, MK ;

WARRIER, RR ;

HONASOGE, S ;

CARVAJAL, DM ;

FAHERTY, DA ;

CONNAUGHTON, SE ;

ANDERSON, TD ;

SARMIENTO, U ;

HUBBARD, BR ;

MURPHY, M .

INTERNATIONAL IMMUNOLOGY, 1994, 6 (01) :157-167

[8] INTERLEUKIN-12 IS REQUIRED FOR THE T-LYMPHOCYTE-INDEPENDENT INDUCTION OF INTERFERON-GAMMA BY AN INTRACELLULAR PARASITE AND INDUCES RESISTANCE IN T-CELL-DEFICIENT HOSTS [J].

GAZZINELLI, RT ;

HIENY, S ;

WYNN, TA ;

WOLF, S ;

SHER, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :6115-6119

[9]

HAYGLASS KT, 1991, J IMMUNOL, V147, P2455

[10] DEVELOPMENT OF TH1 CD4+ T-CELLS THROUGH IL-12 PRODUCED BY LISTERIA-INDUCED MACROPHAGES [J].

HSIEH, CS ;

MACATONIA, SE ;

TRIPP, CS ;

WOLF, SF ;

OGARRA, A ;

MURPHY, KM .

SCIENCE, 1993, 260 (5107) :547-549