CORRECTION OF COBALAMIN MALABSORPTION IN PANCREATIC INSUFFICIENCY WITH A COBALAMIN ANALOG THAT BINDS WITH HIGH AFFINITY TO R-PROTEIN BUT NOT TO INTRINSIC-FACTOR - INVIVO EVIDENCE THAT A FAILURE TO PARTIALLY DEGRADE R-PROTEIN IS RESPONSIBLE FOR COBALAMIN MALABSORPTION IN PANCREATIC INSUFFICIENCY

被引：85

作者：

ALLEN, RH

SEETHARAM, B

ALLEN, NC

PODELL, ER

ALPERS, DH

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,DIV GASTROENTEROL,ST LOUIS,MO 63110

[2] UNIV COLORADO,MED CTR,DEPT MED,DIV HEMATOL,DENVER,CO 80262

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1978年 / 61卷 / 06期

关键词：

D O I：

10.1172/JCI109083

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：1628 / 1634

页数：7

共 16 条

[1]

Allen R H, 1975, Prog Hematol, V9, P57

[2] EFFECT OF PROTEOLYTIC-ENZYMES ON BINDING OF COBALAMIN TO R-PROTEIN AND INTRINSIC-FACTOR - INVITRO EVIDENCE THAT A FAILURE TO PARTIALLY DEGRADE R-PROTEIN IS RESPONSIBLE FOR COBALAMIN MALABSORPTION IN PANCREATIC INSUFFICIENCY [J].

ALLEN, RH ;

SEETHARAM, B ;

PODELL, E ;

ALPERS, DH .

JOURNAL OF CLINICAL INVESTIGATION, 1978, 61 (01) :47-54

[3]

ALLEN RH, 1977, BLOOD, V50, P88

[4]

BURGER RL, 1974, J BIOL CHEM, V249, P7220

[5] MALABSORPTION OF CRYSTALLINE VITAMIN-B12 IN CYSTIC-FIBROSIS [J].

DEREN, JJ ;

ARORA, B ;

TOSKES, PP ;

HANSELL, J ;

SIBINGA, MS .

NEW ENGLAND JOURNAL OF MEDICINE, 1973, 288 (18) :949-950

[6]

GILBERT HS, 1974, BLOOD, V44, P926

[7] NATURE OF VITAMIN B12 BINDING .3. THERMODYNAMICS OF BINDING TO HUMAN INTRINSIC FACTOR AND TRANSCOBALAMINS [J].

HIPPE, E ;

OLESEN, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1971, 243 (01) :83-&

[8] ISOLATION AND CHARACTERIZATION OF AN ABNORMAL HUMAN INTRINSIC-FACTOR [J].

KATZ, M ;

MEHLMAN, CS ;

ALLEN, RH .

JOURNAL OF CLINICAL INVESTIGATION, 1974, 53 (05) :1274-1283

[9] ABSORPTION, PLASMA TRANSPORT, AND CELLULAR RETENTION OF COBALAMIN ANALOGS IN RABBIT - EVIDENCE FOR EXISTENCE OF MULTIPLE MECHANISMS THAT PREVENT ABSORPTION AND TISSUE DISSEMINATION OF NATURALLY OCCURRING COBALAMIN ANALOGS [J].

KOLHOUSE, JF ;

ALLEN, RH .

JOURNAL OF CLINICAL INVESTIGATION, 1977, 60 (06) :1381-1392

[10]

MATUCHANSKY C, 1974, GASTROENTEROLOGY, V67, P406

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