ANALGESIA TO PAIN STIMULI IN SCHIZOPHRENICS AND ITS REVERSAL BY NALTREXONE

被引：70

作者：

DAVIS, GC ^{[1
]}

BUCHSBAUM, MS ^{[1
]}

VANKAMMEN, DP ^{[1
]}

BUNNEY, WE ^{[1
]}

机构：

[1] NIMH, 9000 ROCKVILLE PIKE, BLDG 10, RM 2N212, BETHESDA, MD 20205 USA

来源：

PSYCHIATRY RESEARCH | 1979年 / 1卷 / 01期

关键词：

naltrexone; pain; Schizophrenia; signal detection analysis; somatosensory evoked potentials;

D O I：

10.1016/0165-1781(79)90029-5

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Psychophysical pain ratings and somatosensory evoked potentials (EP) were studied in 17 off-medication patients with schizophrenia and 17 age and sex matched normal controls. Of the 17 schizophrenic patients, 5 participated in a clinical trial of naltrexone. In comparison with normal controls, schizophrenic patients were significantly more insensitive to painful stimulation (based on nonparametric analogs of d''from signal detection analysis) and had significantly smaller somatosensory EP to painful stimuli. Schizophrenics treated with naltrexone showed significant increases in EP amplitude at higher stimulus intensities and hyperalgesic effects on pain ratings.

引用

页码：61 / 69

页数：9

共 38 条

[1]

Buchsbaum, The middle evoked response components and schizophrenia, Schizophrenia Bulletin, 3, (1977)

[2]

Buchsbaum, Davis, Application of somatosensory event related potentials to experimental pain and the pharmacology of analgesia, Human Evoked Potentials: Applications and Problems, (1979)

[3]

Buchsbaum, Davis, Bunney, Naloxone alters pain perception and somatosensory evoked potentials in normal subjects, Nature, 270, (1977)

[4]

Chapman, Murphy, Butler, Analgesic strength of 33 percent nitrous oxide: A signal detection theory evaluation, Science, 179, (1972)

[5]

Clark, Sensory decision theory analysis of the placebo effect on the criterion for pain and thermal sensitivity (d'), Journal of Abnormal Psychology, 74, (1969)

[6]

Clark, Pain sensitivity and the report of pain An introduction to sensory decision theory, Anesthesiology, 10, (1974)

[7]

Clark, Goodman, Effects of suggestion on d' and Cx for pain detection and pain tolerance, Journal of Abnormal Psychology, 83, (1974)

[8]

Clark, Mehl, Thermal pain: Sensory (d') and criterion (Cx) differences between psychiatric patients and normals, Presented at the 21st International Congress of Psychology, (1976)

[9]

Davis, Buchsbaum, Bunney, Naloxone decreases diurnal variation in pain sensitivity and somatosensory evoked potentials, Life Sciences, 23, (1978)

[10]

Davis, Buchsbaum, Bunney, Research in endorphins and schizophrenia, Schizophrenia Bulletin, 5, (1979)

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