MICROALBUMINURIA AND CARDIOVASCULAR RISK-FACTORS IN TYPE-2 DIABETES-MELLITUS

被引：47

作者：

ALLAWI, J ^{[1
]}

JARRETT, RJ ^{[1
]}

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,DIV COMMUNITY HLTH,GUYS CAMPUS,LONDON SE1 9RT,ENGLAND

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 02期

关键词：

Albumin excretion; Blood pressure; Cardiovascular disease; Heart rate; Type; 2; diabetes;

D O I：

10.1111/j.1464-5491.1990.tb01344.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prospective studies have shown that increased urinary albumin excretion is a risk factor for cardiovascular morbidity and mortality in patients with Type 2 diabetes mellitus, but the nature of the association remains unknown. Eighty‐five patients aged less than 65 years and not treated with insulin were studied. The overnight albumin excretion rate (AER) was measured in each patient and analysed in relation to several putative risk factors for cardiovascular disease. AER was used both as a continuous variable and after dividing patients into high‐risk (AER ≥ 10 μg min−1) and low‐risk (AER < 10 μg min−1) groups. By both methods of analysis AER was significantly correlated with both seated and supine diastolic blood pressure levels and with resting heart rate. Body mass index and waist—hip ratio appeared higher and HDL‐cholesterol lower in the at‐risk group, but differences were not statistically significant. The level of Factor VII was not significantly lower in the at‐risk group. Little of the cardiovascular risk associated with raised AER can be attributed to associations with conventional risk factors. 1990 Diabetes UK

引用

页码：115 / 118

页数：4

共 20 条

[1]

Jarrett RJ, Viberti GC, Argyropoulos A., Et al., Microalbuminuria predicts mortality in non‐insulin‐dependent diabetics, Diabetic Med, 1, pp. 7-19, (1984)

[2]

Mogensen CE, Microalbuminuria predicts clinical proteinuria and early mortality in maturity‐onset diabetes, New Engl J Med, 310, pp. 356-360, (1984)

[3]

Schmitz A., Vaeth M., Microalbuminuria: a major risk factor in non‐insulin‐dependent diabetes. A 10‐year follow‐up study of 503 patients, Diabetic Med, 5, pp. 126-134, (1988)

[4]

Lapidus L., Bengtsson C., Larsson B., Et al., Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow‐up of participants in the population study of women in Gothenburg, Sweden, Br Med J, 289, pp. 1257-1261, (1984)

[5]

Keen H., Chlouverakis C., An immunoassay for urinary albumin at low concentrations, Lancet, 2, pp. 913-916, (1963)

[6]

Lopes-Virella MF, Stone P., Ellis S., Et al., Cholesterol determination in high density lipoproteins separated by three different methods, Clin Chem, 23, pp. 882-884, (1977)

[7]

Brozovic M., Stirling Y., Harricks C., Et al., Factor VII in an industrial population, Br J Haematol, 28, pp. 381-391, (1974)

[8]

SAS User's Guide: Basics, Version 5, (1985)

[9]

Mattock MB, Keen H., Viberti GC, Et al., Coronary heart disease and urinary albumin excretion rate in Type 2 (non‐insulin‐dependent) diabetic patients, Diabetologia, 31, pp. 82-87, (1988)

[10]

Garancini P., Gallus G., Calori G., Et al., Microalbuminuria and its associated risk factors in a representative sample of Italian Type II diabetics, J Diabetic Complications, 1, pp. 12-15, (1988)

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