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LINKAGE OF THE ERYTHROID TRANSCRIPTION FACTOR GENE (GF-1) TO THE PROXIMAL REGION OF THE X-CHROMOSOME OF MICE

被引：12
作者：
CHAPMAN, VM
STEPHENSON, DA
MULLINS, LJ
KEITZ, BT
DISTECHE, C
ORKIN, SH
机构：
[1] GERMAN INST HIGH BLOOD PRESSURE RES,HEIDELBERG,GERMANY
[2] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT PEDIAT,HOWARD HUGHES MED INST,BOSTON,MA 02115
[3] UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195
来源：
GENOMICS | 1991年 / 9卷 / 02期
关键词：
D O I：
10.1016/0888-7543(91)90258-G
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We have used a cDNA probe for mouse Gf-1 gene that encodes the erythroid cell transcription factor to identify genetic variation in genomic DNA between Mus species. The segregation of Gf-1 DNA variation was analyzed in Mus species crosses that have been previously typed for the segregation of more than 30 genes spanning 80 cM of the mouse X chromosome from the centromere to the border of the X-Y pairing region. We identified a single X chromosome locus in the mouse, Gf-1, and an analysis of recombinants from 203 backcross progeny mapped Gf-1 to the proximal portion of the chromosome, coincident with the Cybb locus and proximal to Otc gene locus. A gene order of centromere, DXWas70, Cybb Gf-1, Otc, Timp was established for the mouse X chromosome, which is in agreement with the map position observed on the human X chromosome. © 1991.
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页码：309 / 313
页数：5
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