FINITE LIFE-SPAN OF HYBRIDS FORMED BY FUSION OF DIFFERENT SIMIAN VIRUS-40-IMMORTALIZED HUMAN CELL-LINES

被引：34

作者：

WHITAKER, NJ ^{[1
]}

KIDSTON, EL ^{[1
]}

REDDEL, RR ^{[1
]}

机构：

[1] CHILDRENS MED RES FDN,POB 61,CAMPERDOWN,NSW 2050,AUSTRALIA

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 02期

关键词：

D O I：

10.1128/JVI.66.2.1202-1206.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Simian virus 40 (SV40) genes are able to induce immortalization of normal human cells after a culture crisis during which unknown cellular genetic changes presumably occur. To determine whether these genetic changes are always identical, we performed somatic cell hybridization analysis of an SV40-immortalized human bronchial epithelial cell line, BET-1A. Fusion of BET-1A with an SV40-immortalized fibroblast cell line resulted in hybrids that senesced, indicating that these cell lines are in different complementation groups for immortalization.

引用

页码：1202 / 1206

页数：5

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