THE ROLES OF COENZYME Q(10) AND VITAMIN-E ON THE PEROXIDATION OF HUMAN LOW-DENSITY-LIPOPROTEIN SUBFRACTIONS

被引：89

作者：

ALLEVA, R ^{[1
]}

TOMASETTI, M ^{[1
]}

BATTINO, M ^{[1
]}

CURATOLA, G ^{[1
]}

LITTARRU, GP ^{[1
]}

FOLKERS, K ^{[1
]}

机构：

[1] UNIV TEXAS,INST BIOMED RES,AUSTIN,TX 78712

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 20期

关键词：

FATTY ACIDS;

D O I：

10.1073/pnas.92.20.9388

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of our study was to investigate the relationships between the levels of coenzyme Q(10) (CoQ(10)) and vitamin E and the levels of hydroperoxide in three subfractions of low density lipoproteins (LDL) that were isolated from healthy donors, LDL(3), the densest of the three subfractions, has shown statistically significant lower levels of CoQ(10) and vitamin E, which were associated with higher hydroperoxide levels when compared with the lighter counterparts. After CoQ(10) supplementation, all three LDL subfractions had significantly increased CoQ(10) Levels. In particular, LDL(3) showed the highest CoQ(10) increase when compared with LDL(1) and LDL(2) and was associated with a significant decrease in hydroperoxide level. These results support the hypothesis that the CoQ(10) endowment in subfractions of LDL affects their oxidizability, and they have important implications for the treatment of disease.

引用

页码：9388 / 9391

页数：4

共 23 条

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