IDENTIFICATION OF A SET OF GENES WITH DEVELOPMENTALLY DOWN-REGULATED EXPRESSION IN THE MOUSE-BRAIN

被引：469

作者：

KUMAR, S ^{[1
]}

TOMOOKA, Y ^{[1
]}

NODA, M ^{[1
]}

机构：

[1] INST PHYS & CHEM RES, TSUKUBA LIFE SCI CTR, CELL BIOL LAB, KOYADAI, TSUKUBA 305, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91747-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using a subtraction cloning approach, we have isolated a set of cDNA clones from mouse neural precursor cells whose respective mRNA levels are down-regulated during the development of mouse brain. Single stranded DNA prepared from neuronal precursor cell cDNA library in lambda Zap vector was subtracted with poly (A)+ RNA prepared from postnatal and adult mouse brain to obtain several clones which show developmental down-regulation of expression. Their patterns of expression indicate that these genes may play important roles during the embryonic development and differentiation of central nervous system. © 1992.

引用

页码：1155 / 1161

页数：7

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