NIFEDIPINE IN THE TREATMENT OF PRINZMETALS (VARIANT) ANGINA

被引:138
作者
GOLDBERG, S
REICHEK, N
WILSON, J
HIRSHFELD, JW
MULLER, J
KASTOR, JA
机构
[1] HOSP UNIV PENN, CARDIOVASC SECT, CARDIAC CATHETERIZAT LAB, PHILADELPHIA, PA 19104 USA
[2] UNIV PENN, SCH MED, DEPT MED, CARDIOVASC SECT, PHILADELPHIA, PA 19104 USA
[3] PETER BENT BRIGHAM HOSP, DIV CARDIOVASC, BOSTON, MA 02115 USA
[4] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
关键词
D O I
10.1016/0002-9149(79)90201-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The clinical response to therapy with the calcium-blocking agent nifedipine was assessed in 12 patients with variant angina pectoris who were 44 to 67 years old. Five patients had vasospasm of the left anterior descending coronary artery, and seven had spasm of a dominant right coronary artery. Before nifedipine therapy, the frequency of anginal attacks per 24 hour period ranged from 1 to 12, with ventricular tachycardia accompanying ischemic episodes in 7 of 12 patients and high grade atrioventricular block occurring in 2 patients. After therapy with nifedipine, 11 of 12 patients had initial relief of symptoms, and 7 of the 11 had long-term relief. Withdrawal of nifedipine led to recurrence of angina on six occasions in four patients. Provocative testing in the cardiac catheterization laboratory by means of the cold pressor test in one patient and ergonovine maleate in another before and after nifedipine administration showed that this agent can block both alpha adrenergic- and ergonovine-induced vasospasm. Nifedipine may have a significant role in the therapy of angina caused by coronary spasm. © 1979.
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收藏
页码:804 / 810
页数:7
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