MOLECULAR-CLONING OF A NOVEL C-TYPE OR GAMMA-TYPE CHEMOKINE, SCM-1

被引：89

作者：

YOSHIDA, T ^{[1
]}

IMAI, T ^{[1
]}

KAKIZAKI, M ^{[1
]}

NISHIMURA, M ^{[1
]}

YOSHIE, O ^{[1
]}

机构：

[1] SHIONOGI INST MED SCI,SETTSU,OSAKA 566,JAPAN

来源：

FEBS LETTERS | 1995年 / 360卷 / 02期

关键词：

CHEMOKINE; MOLECULAR CLONING; LYMPHOTACTIN;

D O I：

10.1016/0014-5793(95)00093-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From human PBMC stimulated with PEA, we have isolated cDNA clones encoding a novel cytokine named SCM-1, which is significantly related to the CC and the CXC chemokines but has only the 2nd and the 4th of the four cysteines conserved in these proteins, Its gene is also distinctly mapped to human chromosome 1. SCM-1 is strongly induced in human PBMC and Jurkat T cells by PHA stimulation. Among various human tissues, SCM-1 is expressed most strongly in spleen, SCM-1 is found to be 60.5% identical to lymphotactin, a recently described murine lymphocyte-specific chemokine, which also retains only two cysteines, SCM-1 and lymphotactin may thus represent the human and murine prototypes of a novel C or gamma type chemokine family.

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页码：155 / 159

页数：5

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