KAI1, A METASTASIS SUPPRESSOR GENE FOR PROSTATE-CANCER ON HUMAN-CHROMOSOME 11P11.2

被引：722

作者：

DONG, JT

LAMB, PW

RINKERSCHAEFFER, CW

VUKANOVIC, J

ICHIKAWA, T

ISAACS, JT

BARRETT, JC

机构：

[1] NIEHS, MOLEC CARCINOGENESIS LAB, ENVIRONM CARCINOGENESIS PROGRAM, RES TRIANGLE PK, NC 27709 USA

[2] JOHNS HOPKINS UNIV, SCH MED, JOHNS HOPKINS ONCOL CTR, BALTIMORE, MD 21231 USA

[3] CHIBA UNIV, SCH MED, DEPT UROL, CHIBA 260, JAPAN

来源：

SCIENCE | 1995年 / 268卷 / 5212期

关键词：

D O I：

10.1126/science.7754374

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1, was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites. KAI1 is evolutionarily conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.

引用

页码：884 / 886

页数：3

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