THE ANTICONVULSANT MK-801 IS A POTENT N-METHYL-D-ASPARTATE ANTAGONIST

被引：1884

作者：

WONG, EHF

KEMP, JA

PRIESTLEY, T

KNIGHT, AR

WOODRUFF, GN

IVERSEN, LL

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1986年 / 83卷 / 18期

关键词：

D O I：

10.1073/pnas.83.18.7104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：7104 / 7108

页数：5

共 25 条

[1] THE DISSOCIATIVE ANESTHETICS, KETAMINE AND PHENCYCLIDINE, SELECTIVELY REDUCE EXCITATION OF CENTRAL MAMMALIAN NEURONS BY N-METHYL-ASPARTATE [J].

ANIS, NA ;

BERRY, SC ;

BURTON, NR ;

LODGE, D .

BRITISH JOURNAL OF PHARMACOLOGY, 1983, 79 (02) :565-575

[2]

CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099

[3] CENTRAL SYMPATHOMIMETIC ACTIVITY OF (+)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO [A,D]CYCLOHEPTEN-5, 10-IMINE (MK-801), A SUBSTANCE WITH POTENT ANTICONVULSANT, CENTRAL SYMPATHOMIMETIC, AND APPARENT ANXIOLYTIC PROPERTIES [J].

CLINESCHMIDT, BV ;

MARTIN, GE ;

BUNTING, PR ;

PAPP, NL .

DRUG DEVELOPMENT RESEARCH, 1982, 2 (02) :135-145

[4] ANTICONVULSANT ACTIVITY OF (+)-5-METHYL-10, 11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5, 10-IMINE (MK-801), A SUBSTANCE WITH POTENT ANTICONVULSANT, CENTRAL SYMPATHOMIMETIC, AND APPARENT ANXIOLYTIC PROPERTIES [J].

CLINESCHMIDT, BV ;

MARTIN, GE ;

BUNTING, PR .

DRUG DEVELOPMENT RESEARCH, 1982, 2 (02) :123-134

[5] RESTORATION OF SHOCK-SUPPRESSED BEHAVIOR BY TREATMENT WITH (+)-5-METHYL-10, 11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5, 10-IMINE (MK-801), A SUBSTANCE WITH POTENT ANTICONVULSANT, CENTRAL SYMPATHOMIMETIC, AND APPARENT ANXIOLYTIC PROPERTIES [J].

CLINESCHMIDT, BV ;

WILLIAMS, M ;

WITOSLAWSKI, JJ ;

BUNTING, PR ;

RISLEY, EA ;

TOTARO, JA .

DRUG DEVELOPMENT RESEARCH, 1982, 2 (02) :147-163

[6] ACTIONS OF D-FORMS AND L-FORMS OF 2-AMINO-5-PHOSPHONOVALERATE AND 2-AMINO-4-PHOSPHONOBUTYRATE IN THE CAT SPINAL-CORD [J].

DAVIES, J ;

WATKINS, JC .

BRAIN RESEARCH, 1982, 235 (02) :378-386

[7] THE EFFECTS OF A SERIES OF OMEGA-PHOSPHONIC ALPHA-CARBOXYLIC AMINO-ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID-INDUCED RESPONSES IN ISOLATED SPINAL-CORD PREPARATIONS [J].

EVANS, RH ;

FRANCIS, AA ;

JONES, AW ;

SMITH, DAS ;

WATKINS, JC .

BRITISH JOURNAL OF PHARMACOLOGY, 1982, 75 (01) :65-75

[8] ACIDIC AMINO-ACID BINDING-SITES IN MAMMALIAN NEURONAL MEMBRANES - THEIR CHARACTERISTICS AND RELATIONSHIP TO SYNAPTIC RECEPTORS [J].

FOSTER, AC ;

FAGG, GE .

BRAIN RESEARCH REVIEWS, 1984, 7 (02) :103-164

[9] QUANTITATIVE STUDIES ON SOME ANTAGONISTS OF N-METHYL D-ASPARTATE IN SLICES OF RAT CEREBRAL-CORTEX [J].

HARRISON, NL ;

SIMMONDS, MA .

BRITISH JOURNAL OF PHARMACOLOGY, 1985, 84 (02) :381-391

[10] KETAMINE AND PHENCYCLIDINE CAUSE A VOLTAGE-DEPENDENT BLOCK OF RESPONSES TO L-ASPARTIC ACID [J].

HONEY, CR ;

MILJKOVIC, Z ;

MACDONALD, JF .

NEUROSCIENCE LETTERS, 1985, 61 (1-2) :135-139

← 1 2 3 →