IDENTIFICATION OF A MEMBER OF MOUSE SEMAPHORIN FAMILY

被引：59

作者：

INAGAKI, S

FURUYAMA, T

IWAHASHI, Y

机构：

[1] OSAKA UNIV,FAC MED,DEPT ANAT 2,SUITA 565,OSAKA,JAPAN

[2] OSAKA UNIV,FAC MED,DEPT OPHTHALMOL,SUITA 565,OSAKA,JAPAN

来源：

FEBS LETTERS | 1995年 / 370卷 / 03期

关键词：

SEMAPHORIN; COLLAPSIN; AXON GUIDANCE; CLONING; TRANSMEMBRANE; MOUSE;

D O I：

10.1016/0014-5793(95)00850-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Grasshopper semaphorin I (Sema I) and its related proteins, thick collapsin and mouse Sema III contribute to the axon guidance by their repellent actions [5,9,12], We have identified a member of semaphorin gene family from the mouse brain and named it M-Sema F, The N-terminal encodes a semaphorin domain that is similar between Sema I-III [6] followed by a single putative immunoglobulin-like domain, a transmembrane domain, and a proline-rich intracellular domain, M-Sema F mRNA is expressed widely in the nervous tissues during development, These suggest that M-Sema F is a transmembrane member of the semaphorin family of the vertebrate which may function in the developing neuronal network.

引用

页码：269 / 272

页数：4

共 15 条

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CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[2] AXON GUIDANCE - A COMPELLING CASE FOR REPELLING GROWTH [J].