ENHANCEMENT OF GLUTATHIONE LEVELS IN MOUSE PERITONEAL-MACROPHAGES BY SODIUM ARSENITE, CADMIUM CHLORIDE AND GLUCOSE GLUCOSE-OXIDASE

被引：84

作者：

BANNAI, S ^{[1
]}

SATO, H ^{[1
]}

ISHII, T ^{[1
]}

TAKETANI, S ^{[1
]}

机构：

[1] KANSAI MED UNIV,DEPT HYG,MORIGUCHI,OSAKA 570,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1092卷 / 02期

关键词：

GLUTATHIONE LEVEL; HYDROGEN PEROXIDE; CYSTINE TRANSPORT; (MOUSE PERITONEAL MACROPHAGE);

D O I：

10.1016/0167-4889(91)90153-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutathione content of mouse peritoneal macrophages markedly increased when they were exposed to insulting agents like sodium arsenite, cadmium chloride, and glucose / glucose oxidase which generates hydrogen peroxide. This increase was attributed to the induction of the cystine transport activity by these agents. The transport activity for other amino acids was not induced, but rather diminished by these agents. Heat shock treatment did not induce the cystine transport activity, nor did it augment glutathione. Since glutathione protects cells against the cytotoxic effects of these agents, the induction of the cystine transport activity constitutes a protective mechanism related to the stress caused by the agents. The protein component(s) for cystine transport may fall into the category of the stress protein.

引用

页码：175 / 179

页数：5

共 20 条

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[2]

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